NP_004043.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,541 Da
NCBI Official Full Name
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
NCBI Official Synonym Full Names
BCL2 interacting protein 3
NCBI Official Synonym Symbols
NCBI Protein Information
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
UniProt Protein Name
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
UniProt Synonym Gene Names
UniProt Entry Name
BNIP3_HUMAN
NCBI Summary for BNIP3
This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014]
UniProt Comments for BNIP3
BNIP3: Apoptosis-inducing protein that, which can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Also can interact with adenovirus E1B 19 kDa protein or Epstein-Barr virus BHRF1. Belongs to the NIP3 family.
Protein type: Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 10q26.3
Cellular Component: cytoplasm; dendrite; endoplasmic reticulum; integral to mitochondrial outer membrane; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; nuclear envelope; nucleoplasm; nucleus
Molecular Function: GTPase binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process: apoptosis; cell death; defense response to virus; induction of apoptosis by granzyme; mitochondrial fragmentation during apoptosis; negative regulation of apoptosis; negative regulation of membrane potential; neuron apoptosis; positive regulation of apoptosis; positive regulation of autophagy; positive regulation of macroautophagy; positive regulation of programmed cell death; positive regulation of protein complex disassembly; regulation of mitochondrial membrane permeability; response to hypoxia
Research Articles on BNIP3
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Products associated with BNIP3 elisa kit
Pathways associated with BNIP3 elisa kit
Diseases associated with BNIP3 elisa kit
Organs/Tissues associated with BNIP3 elisa kit
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