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PKBA elisa kit :: Plant Protein Kinase B Alpha (PKBA) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9374217 PKBA elisa kit
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Protein Kinase B Alpha (PKBA), ELISA Kit

 Also Known As   

Plant Protein Kinase B Alpha (PKBA) ELISA Kit

 Product Gene Name   

PKBA elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Species Reactivity    Plant
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PKBA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PKBA purchase    MBS9374217 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Protein Kinase B Alpha (PKBA) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PKBA. The ELISA analytical biochemical technique of the MBS9374217 kit is based on PKBA antibody-PKBA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PKBA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PKBA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for PKBA. It may not necessarily be applicable to this product.
 NCBI GI #    22653384
 NCBI GeneID    11651
 NCBI Accession #    AAN04036.1 [Other Products]
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 UniProt Secondary Accession #    Q62274; Q6GSA6 [Other Products]
 UniProt Related Accession #    P31750 [Other Products]
 Molecular Weight    55,707 Da
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 NCBI Official Full Name    protein kinase B-alpha
 NCBI Official Synonym Full Names    thymoma viral proto-oncogene 1
 NCBI Official Symbol    Akt1 [Similar Products]
 NCBI Official Synonym Symbols   
Akt; PKB; Rac; PKB/Akt; PKBalpha
[Similar Products]
 NCBI Protein Information    RAC-alpha serine/threonine-protein kinase
 UniProt Protein Name    RAC-alpha serine/threonine-protein kinase
 UniProt Synonym Protein Names   
AKT1 kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha; Thymoma viral proto-oncogene
 Protein Family    RAC family serine/threonine-protein kinase
 UniProt Gene Name    Akt1 [Similar Products]
 UniProt Synonym Gene Names    Akt; Rac; PKB; PKB alpha [Similar Products]
 UniProt Entry Name    AKT1_MOUSE
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 NCBI Summary for PKBA    This gene encodes the founding member of the Akt serine-threonine protein kinase gene family that also includes Akt2 and Akt3. This kinase is a major downstream effector of the phosphatidylinositol 3-kinase (PI3K) pathway that mediates the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). It is activated through recruitment to cellular membranes by PI3K lipid products and by phosphorylation by 3-phosphoinositide dependent kinase-1. It then further phosphorylates different downstream proteins in response to various extracellular signals and thus plays a pivotal role in mediating a variety of cellular processes, such as glucose metabolism, glycogen biosynthesis, protein synthesis and turn over, inflammatory response, cell survival (anti-apoptosis) and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
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 UniProt Comments for PKBA    Akt1: an oncogenic AGC kinase that plays a critical role in regulating cell survival and metabolism in many different signaling pathways. Dual phosphorylation is required for its activation. T308 is phosphorylated by PDK1 in the PI3 kinase pathway, and S473 is phosphorylated by mTOR in the mTORC2 pathway. The 'Lys-63'-linked ubiquitination of AKT1 by TRAF6 is important for its translocation to the plasma membrane, phosphorylation, and activation. When Akt is fully phosphorylated it translocates into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its proteosomal degradation. Hyperactive or overexpressed in a number of cancers including breast, prostate, lung, pancreatic, liver, ovarian and colorectal. Over 160 protein substrates are known including many that regulate transcription, metabolism, apoptosis, cell cycle, and growth.

Protein type: Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, AGC; AGC group; AKT family

Cellular Component: cytoplasm; cytosol; intercellular junction; microtubule cytoskeleton; mitochondrion; nucleus; plasma membrane; protein complex; spindle; vesicle

Molecular Function: ATP binding; enzyme binding; GTPase activating protein binding; identical protein binding; kinase activity; nitric-oxide synthase regulator activity; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding; protein kinase activity; protein kinase binding; protein kinase C binding; protein phosphatase 2A binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity

Biological Process: activated T cell apoptosis; aging; anagen; apoptotic mitochondrial changes; cell projection organization and biogenesis; cellular response to insulin stimulus; cytoskeleton organization and biogenesis; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; germ cell development; glucose homeostasis; glucose metabolic process; glucose transport; glycogen biosynthetic process; glycogen metabolic process; inflammatory response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; lipopolysaccharide-mediated signaling pathway; maternal placenta development; myelin maintenance in the peripheral nervous system; negative regulation of apoptosis; negative regulation of autophagy; negative regulation of caspase activity; negative regulation of cell size; negative regulation of fatty acid beta-oxidation; negative regulation of JNK cascade; negative regulation of protein kinase activity; negative regulation of proteolysis; osteoblast differentiation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of apoptosis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell growth; positive regulation of cellular protein metabolic process; positive regulation of endodeoxyribonuclease activity; positive regulation of endothelial cell proliferation; positive regulation of fat cell differentiation; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of lipid biosynthetic process; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein amino acid phosphorylation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of vasoconstriction; protein amino acid phosphorylation; protein catabolic process; protein import into nucleus, translocation; protein kinase B signaling cascade; protein ubiquitination; regulation of cell migration; regulation of glycogen biosynthetic process; regulation of myelination; regulation of protein localization; response to DNA damage stimulus; response to food; response to hormone stimulus; response to organic substance; signal transduction; spinal cord development; striated muscle cell differentiation; translation
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 Research Articles on PKBA    1. data suggest that folic acid promotes the differentiation of C2C12 cells through the activation of the Akt pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PKBA elisa kitPathways associated with PKBA elisa kit
 Reference Product  PubMed Publications
 Pten elisa kit  >602 publications with PKBA and Pten
 Mtor elisa kit  >535 publications with PKBA and Mtor
 Foxo1 elisa kit  >152 publications with PKBA and Foxo1
 Nos3 elisa kit  >129 publications with PKBA and Nos3
 Cdkn1b elisa kit  >121 publications with PKBA and Cdkn1b
 Foxo3 elisa kit  >73 publications with PKBA and Foxo3
 Tsc2 elisa kit  >47 publications with PKBA and Tsc2
 Rictor elisa kit  >29 publications with PKBA and Rictor
 Hsp90aa1 elisa kit  >5 publications with PKBA and Hsp90aa1
 Hsp90ab1 elisa kit  >2 publications with PKBA and Hsp90ab1
 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AKT Phosphorylates Targets In The Cytosol Pathway antibodies  AKT Phosphorylates Targets In The Cytosol Pathway Diagram
 AKT Phosphorylates Targets In The Nucleus Pathway antibodies  AKT Phosphorylates Targets In The Nucleus Pathway Diagram
 AKT-mediated Inactivation Of FOXO1A Pathway antibodies  AKT-mediated Inactivation Of FOXO1A Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
Diseases associated with PKBA elisa kitOrgans/Tissues associated with PKBA elisa kit
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >454 publications with PKBA and Breast Neoplasms
 Nervous System Diseases Antibodies  >345 publications with PKBA and Nervous System Diseases
 Necrosis Antibodies  >313 publications with PKBA and Necrosis
 Lung Neoplasms Antibodies  >271 publications with PKBA and Lung Neoplasms
 Inflammation Antibodies  >212 publications with PKBA and Inflammation
 Prostatic Neoplasms Antibodies  >207 publications with PKBA and Prostatic Neoplasms
 Neoplasms, Experimental Antibodies  >203 publications with PKBA and Neoplasms, Experimental
 Heart Diseases Antibodies  >166 publications with PKBA and Heart Diseases
 Liver Diseases Antibodies  >151 publications with PKBA and Liver Diseases
 Colorectal Neoplasms Antibodies  >151 publications with PKBA and Colorectal Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >851 publications with PKBA and Blood
 Muscle Antibodies  >730 publications with PKBA and Muscle
 Brain Antibodies  >550 publications with PKBA and Brain
 Lung Antibodies  >433 publications with PKBA and Lung
 Liver Antibodies  >331 publications with PKBA and Liver
 Heart Antibodies  >330 publications with PKBA and Heart
 Bone Antibodies  >193 publications with PKBA and Bone
 Kidney Antibodies  >182 publications with PKBA and Kidney
 Skin Antibodies  >167 publications with PKBA and Skin
 Embryonic Tissue Antibodies  >141 publications with PKBA and Embryonic Tissue
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