NP_058760.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
84,970 Da
NCBI Official Full Name
signal transducer and activator of transcription 5A
NCBI Official Synonym Full Names
signal transducer and activator of transcription 5A
NCBI Official Synonym Symbols
NCBI Protein Information
signal transducer and activator of transcription 5A
UniProt Protein Name
Signal transducer and activator of transcription 5A
UniProt Synonym Protein Names
Mammary gland factor
UniProt Synonym Gene Names
UniProt Entry Name
STA5A_RAT
NCBI Summary for STAT5A
member of the STAT family of transcription factors; may mediate the biological actions of several interleukin factors (IL2, IL3, IL7) and growth hormones; may be associated with mammary gland function [RGD, Feb 2006]
UniProt Comments for STAT5A
STAT5A: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 fusion protein is essential for the tumorigenesis. Induces the expression of BCL2L1/BCL-X(L) in the mouse, suggesting an antiapoptotic function of this protein. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.
Protein type: DNA-binding; Transcription factor; Motility/polarity/chemotaxis; Oncoprotein
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: DNA binding; double-stranded DNA binding; protein binding; protein phosphatase binding; sequence-specific DNA binding; signal transducer activity; transcription factor activity
Biological Process: 2-oxoglutarate metabolic process; allantoin metabolic process; citrate metabolic process; creatine metabolic process; creatinine metabolic process; cytokine and chemokine mediated signaling pathway; development of secondary female sexual characteristics; development of secondary male sexual characteristics; fatty acid metabolic process; female pregnancy; isoleucine metabolic process; JAK-STAT cascade; lactation; luteinization; mammary gland development; mammary gland involution; natural killer cell differentiation; negative regulation of apoptosis; negative regulation of erythrocyte differentiation; negative regulation of mast cell apoptosis; oxaloacetate metabolic process; peptidyl-tyrosine phosphorylation; Peyer's patch development; positive regulation of activated T cell proliferation; positive regulation of B cell differentiation; positive regulation of blood vessel endothelial cell migration; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; positive regulation of gamma-delta T cell differentiation; positive regulation of inflammatory response; positive regulation of interleukin-2 biosynthetic process; positive regulation of lymphocyte differentiation; positive regulation of mitotic cell cycle; positive regulation of multicellular organism growth; positive regulation of natural killer cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of transcription from RNA polymerase II promoter; regulation of cell adhesion; regulation of epithelial cell differentiation; regulation of multicellular organism growth; regulation of steroid metabolic process; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; reproductive process in a multicellular organism; response to ethanol; response to nutrient levels; response to peptide hormone stimulus; sequestering of lipid; succinate metabolic process; T cell differentiation in the thymus; T cell homeostasis; taurine metabolic process; transcription from RNA polymerase II promoter; valine metabolic process
Research Articles on STAT5A
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Products associated with STAT5A elisa kit
Pathways associated with STAT5A elisa kit
Diseases associated with STAT5A elisa kit
Organs/Tissues associated with STAT5A elisa kit
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