NP_001171420.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
27,729 Da
NCBI Official Full Name
synaptonemal complex protein 3
NCBI Official Synonym Full Names
synaptonemal complex protein 3
NCBI Protein Information
synaptonemal complex protein 3
UniProt Protein Name
Synaptonemal complex protein 3
UniProt Synonym Gene Names
UniProt Entry Name
SYCP3_HUMAN
NCBI Summary for SYCP3
This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010]
UniProt Comments for SYCP3
SYCP3: Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Defects in SYCP3 are the cause of spermatogenic failure type 4 (SPGF4). An infertility disorder characterized by azoospermia, a condition of having no sperm present in the ejaculate. Testicular histology shows arrest of spermatogenesis at the pachytene stage of primary spermatocytes. Belongs to the XLR/SYCP3 family.
Chromosomal Location of Human Ortholog: 12q
Cellular Component: lateral element; nucleus
Biological Process: spermatogenesis, exchange of chromosomal proteins
Disease: Spermatogenic Failure 4
Research Articles on SYCP3
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Products associated with SYCP3 elisa kit
Pathways associated with SYCP3 elisa kit
Diseases associated with SYCP3 elisa kit
Organs/Tissues associated with SYCP3 elisa kit
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