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ACMSD elisa kit :: Porcine 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7208956 ACMSD elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD), ELISA Kit

 Also Known As   

Porcine 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD) ELISA Kit

 Product Gene Name   

ACMSD elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    608889
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 Species Reactivity    Porcine
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ACMSD elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ACMSD purchase    MBS7208956 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ACMSD. The ELISA analytical biochemical technique of the MBS7208956 kit is based on ACMSD antibody-ACMSD antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ACMSD antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ACMSD. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ACMSD. It may not necessarily be applicable to this product.
 NCBI GI #    109715856
 NCBI GeneID    130013
 NCBI Accession #    NP_612199.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_138326.2 [Other Products]
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 UniProt Secondary Accession #    Q3B7X3; Q53SR5; Q96KY2 [Other Products]
 UniProt Related Accession #    Q8TDX5 [Other Products]
 Molecular Weight    31,213 Da
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 NCBI Official Full Name    2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
 NCBI Official Synonym Full Names    aminocarboxymuconate semialdehyde decarboxylase
 NCBI Official Symbol    ACMSD [Similar Products]
 NCBI Protein Information    2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; picolinate carboxylase
 UniProt Protein Name    2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
 UniProt Synonym Protein Names   
Picolinate carboxylase
 Protein Family    2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
 UniProt Gene Name    ACMSD [Similar Products]
 UniProt Entry Name    ACMSD_HUMAN
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 NCBI Summary for ACMSD    The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]
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 UniProt Comments for ACMSD    ACMSD: Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. Belongs to the ACMSD family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - tryptophan; Lyase; EC 4.1.1.45

Chromosomal Location of Human Ortholog: 2q21.3

Cellular Component: cytosol

Molecular Function: aminocarboxymuconate-semialdehyde decarboxylase activity; metal ion binding

Biological Process: quinolinate metabolic process; tryptophan catabolic process
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 Research Articles on ACMSD    1. ACMSD is mutated in a family with cortical myoclonus, epilepsy, and parkinsonism. ACMSD mutation contributes to the development of Familial cortical myoclonic tremor and epilepsy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ACMSD elisa kitPathways associated with ACMSD elisa kit
 Reference Product  PubMed Publications
 SYT11 elisa kit  >7 publications with ACMSD and SYT11
 MCCC1 elisa kit  >7 publications with ACMSD and MCCC1
 CCDC62 elisa kit  >6 publications with ACMSD and CCDC62
 QPRT elisa kit  >4 publications with ACMSD and QPRT
 Products by Pathway  Pathway Diagram
 2-amino-3-carboxymuconate Semialdehyde Degradation To Glutaryl-CoA Pathway antibodies  2-amino-3-carboxymuconate Semialdehyde Degradation To Glutaryl-CoA Pathway Diagram
 2-amino-3-carboxymuconate Semialdehyde Degradation To Glutaryl-CoA Pathway antibodies  2-amino-3-carboxymuconate Semialdehyde Degradation To Glutaryl-CoA Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Tryptophan Catabolism Pathway antibodies  Tryptophan Catabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Tryptophan Degradation III (eukaryotic) Pathway antibodies  Tryptophan Degradation III (eukaryotic) Pathway Diagram
Diseases associated with ACMSD elisa kitOrgans/Tissues associated with ACMSD elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >8 publications with ACMSD and Nervous System Diseases
 Fatty Liver Antibodies  >5 publications with ACMSD and Fatty Liver
 Disease Models, Animal Antibodies  >3 publications with ACMSD and Disease Models, Animal
 Kidney Diseases Antibodies  >2 publications with ACMSD and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with ACMSD and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >1 publications with ACMSD and Liver Diseases
 Hypercholesterolemia Antibodies  >1 publications with ACMSD and Hypercholesterolemia
 Insulin Resistance Antibodies  >1 publications with ACMSD and Insulin Resistance
 Liver Neoplasms Antibodies  >1 publications with ACMSD and Liver Neoplasms
 Drug-Induced Liver Injury Antibodies  >1 publications with ACMSD and Drug-Induced Liver Injury
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >26 publications with ACMSD and Liver
 Kidney Antibodies  >14 publications with ACMSD and Kidney
 Brain Antibodies  >6 publications with ACMSD and Brain
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