NP_032281.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
97,040 Da
NCBI Official Full Name
3-hydroxy-3-methylglutaryl-coenzyme A reductase
NCBI Official Synonym Full Names
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
NCBI Protein Information
3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase; 3-hydroxy-3-methylglutaryl-CoA reductase
UniProt Protein Name
3-hydroxy-3-methylglutaryl-coenzyme A reductase
UniProt Synonym Gene Names
UniProt Entry Name
HMDH_MOUSE
UniProt Comments for HMGCR
HMGCR: the rate-limiting enzyme for cholesterol synthesis. Regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by this reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.
Protein type: Membrane protein, integral; EC 1.1.1.34; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Oxidoreductase; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Endoplasmic reticulum
Cellular Component: peroxisomal membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bound organelle; endoplasmic reticulum; integral to membrane
Molecular Function: hydroxymethylglutaryl-CoA reductase (NADPH) activity; protein homodimerization activity; protein phosphatase 2A binding; hydroxymethylglutaryl-CoA reductase activity; oxidoreductase activity; NADP binding; coenzyme binding; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process: steroid metabolic process; negative regulation of MAP kinase activity; cholesterol metabolic process; isoprenoid biosynthetic process; positive regulation of smooth muscle cell proliferation; positive regulation of skeletal muscle development; cholesterol biosynthetic process; positive regulation of stress-activated MAPK cascade; coenzyme A metabolic process; embryonic development; ubiquinone metabolic process; negative regulation of vasodilation; sterol biosynthetic process; positive regulation of cell proliferation; visual learning; lipid metabolic process; steroid biosynthetic process; protein tetramerization; negative regulation of apoptosis
Research Articles on HMGCR
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with HMGCR elisa kit
Diseases associated with HMGCR elisa kit
Organs/Tissues associated with HMGCR elisa kit
|