CAG46678.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,420 Da
NCBI Official Full Name
ALDOA
NCBI Official Synonym Full Names
aldolase A, fructose-bisphosphate
NCBI Official Synonym Symbols
NCBI Protein Information
fructose-bisphosphate aldolase A; muscle-type aldolase; lung cancer antigen NY-LU-1; fructose-1,6-bisphosphate triosephosphate-lyase
UniProt Protein Name
Fructose-bisphosphate aldolase A
UniProt Synonym Protein Names
Lung cancer antigen NY-LU-1; Muscle-type aldolase
UniProt Synonym Gene Names
UniProt Entry Name
ALDOA_HUMAN
NCBI Summary for ALDOA
The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Aug 2011]
UniProt Comments for ALDOA
ALDOA: a glycolytic enzyme that catalyzes D-fructose 1,6-bisphosphate -> glycerone phosphate + D-glyceraldehyde 3-phosphate. Three forms of aldolase are found in vertebrates - aldolase A in muscle, aldolase B in liver and aldolase C in brain.
Protein type: Carbohydrate Metabolism - pentose phosphate pathway; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Lyase; Mitochondrial; Carbohydrate Metabolism - fructose and mannose; EC 4.1.2.13
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: I band; extracellular space; membrane; extracellular region; M band; nucleus; cytosol; actin cytoskeleton
Molecular Function: tubulin binding; identical protein binding; protein binding; cytoskeletal protein binding; fructose-bisphosphate aldolase activity; actin binding
Biological Process: platelet activation; glycolysis; striated muscle contraction; glucose metabolic process; actin filament organization; pathogenesis; protein homotetramerization; gluconeogenesis; muscle maintenance; fructose 1,6-bisphosphate metabolic process; regulation of cell shape; platelet degranulation; ATP biosynthetic process; carbohydrate metabolic process; blood coagulation; fructose metabolic process
Disease: Glycogen Storage Disease Xii
Research Articles on ALDOA
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Products associated with ALDOA elisa kit
Pathways associated with ALDOA elisa kit
Diseases associated with ALDOA elisa kit
Organs/Tissues associated with ALDOA elisa kit
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