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SCNN1B elisa kit :: Porcine Amiloride-sensitive sodium channel subunit beta (SCNN1B) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7249865 SCNN1B elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Amiloride-sensitive sodium channel subunit beta (SCNN1B), ELISA Kit

 Also Known As   

Porcine Amiloride-sensitive sodium channel subunit beta (SCNN1B) ELISA Kit

 Product Gene Name   

SCNN1B elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    600760
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 Species Reactivity    Porcine
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SCNN1B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SCNN1B purchase    MBS7249865 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Amiloride-sensitive sodium channel subunit beta (SCNN1B) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SCNN1B. The ELISA analytical biochemical technique of the MBS7249865 kit is based on SCNN1B antibody-SCNN1B antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SCNN1B antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SCNN1B. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for SCNN1B elisa kit    Neurobiology
NCBI/Uniprot data below describe general gene information for SCNN1B. It may not necessarily be applicable to this product.
 NCBI GI #    124301196
 NCBI GeneID    6338
 NCBI Accession #    NP_000327.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000336.2 [Other Products]
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 UniProt Secondary Accession #    O60891; Q96KG2; Q9UJ32; Q9UMU5; C5HTZ2 [Other Products]
 UniProt Related Accession #    P51168 [Other Products]
 Molecular Weight    77,703 Da
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 NCBI Official Full Name    amiloride-sensitive sodium channel subunit beta
 NCBI Official Synonym Full Names    sodium channel, non-voltage-gated 1, beta subunit
 NCBI Official Symbol    SCNN1B [Similar Products]
 NCBI Official Synonym Symbols   
BESC1; ENaCb; SCNEB; ENaCbeta
[Similar Products]
 NCBI Protein Information    amiloride-sensitive sodium channel subunit beta; beta-ENaC; beta-NaCH; epithelial Na(+) channel subunit beta; epithelial sodium channel beta-2 subunit; epithelial sodium channel beta-3 subunit; sodium channel, nonvoltage-gated 1, beta; nasal epithelial sodium channel beta subunit; nonvoltage-gated sodium channel 1 subunit beta; amiloride-sensitive sodium channel subunit beta 1
 UniProt Protein Name    Amiloride-sensitive sodium channel subunit beta
 UniProt Synonym Protein Names   
Beta-NaCH; Epithelial Na(+) channel subunit beta; Beta-ENaC; ENaCB; Nonvoltage-gated sodium channel 1 subunit beta; SCNEB
 Protein Family    Amiloride-sensitive sodium channel
 UniProt Gene Name    SCNN1B [Similar Products]
 UniProt Synonym Gene Names    Beta-ENaC; ENaCB [Similar Products]
 UniProt Entry Name    SCNNB_HUMAN
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 NCBI Summary for SCNN1B    Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome. [provided by RefSeq, Apr 2009]
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 UniProt Comments for SCNN1B    ENaC-beta: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Defects in SCNN1B are a cause of autosomal recessive pseudohypoaldosteronism type 1 (AR-PHA1). PHA1 is a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. There are 2 forms of PHA1: the autosomal recessive form that is severe, and the dominant form which is milder and due to defects in mineralocorticoid receptor. AR-PHA1 is characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatraemia, hyperkalaemia, metabolic acidosis, failure to thrive and weight loss. The degree of channel function impairment differentially affects the renin-aldosterone system and urinary Na/K ratios, resulting in distinct genotype-phenotype relationships in PHA1 patients. Loss- of-function mutations are associated with a severe clinical course and age-dependent hyperactivation of the renin-aldosterone system. This feature is not observed in patients with missense mutations that reduce but do not eliminate channel function. Markedly reduced channel activity results in impaired linear growth and delayed puberty. Defects in SCNN1B are a cause of Liddle syndrome (LIDDS). It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel. Defects in SCNN1B are the cause of bronchiectasis with or without elevated sweat chloride type 1 (BESC1). A debilitating respiratory disease characterized by chronic, abnormal dilatation of the bronchi and other cystic fibrosis-like symptoms in the absence of known causes of bronchiectasis (cystic fibrosis, autoimmune diseases, ciliary dyskinesia, common variable immunodeficiency, foreign body obstruction). Clinical features include sub-normal lung function, sinopulmonary infections, chronic productive cough, excessive sputum production, and elevated sweat chloride in some cases. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1B subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integral; Channel, sodium

Chromosomal Location of Human Ortholog: 16p12.2-p12.1

Cellular Component: integral to plasma membrane; apical plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: amiloride-sensitive sodium channel activity; protein binding; WW domain binding

Biological Process: sensory perception of taste; sodium ion transport; response to stimulus; sodium ion homeostasis; multicellular organismal water homeostasis; excretion; transmembrane transport

Disease: Bronchiectasis With Or Without Elevated Sweat Chloride 1; Pseudohypoaldosteronism, Type I, Autosomal Recessive; Liddle Syndrome
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 Research Articles on SCNN1B    1. Suggest that beta-ENaC mediates cytotrophoblast migration and increasing beta-ENaC expression by HO-1 induction enhances migration.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SCNN1B elisa kitPathways associated with SCNN1B elisa kit
 Reference Product  PubMed Publications
 SCNN1G elisa kit  >66 publications with SCNN1B and SCNN1G
 SCNN1A elisa kit  >52 publications with SCNN1B and SCNN1A
 CFTR elisa kit  >17 publications with SCNN1B and CFTR
 SGK1 elisa kit  >6 publications with SCNN1B and SGK1
 NEDD4L elisa kit  >1 publications with SCNN1B and NEDD4L
 Products by Pathway  Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 Taste Transduction Pathway antibodies  Taste Transduction Pathway Diagram
 Taste Transduction Pathway antibodies  Taste Transduction Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
Diseases associated with SCNN1B elisa kitOrgans/Tissues associated with SCNN1B elisa kit
 Disease Name  Pubmed Publications
 Bronchiectasis With Or Without Elevated Sweat Chloride 1 Antibodies  >63 publications with SCNN1B and Bronchiectasis With Or Without Elevated Sweat Chloride 1
 Hypertension Antibodies  >55 publications with SCNN1B and Hypertension
 Cardiovascular Diseases Antibodies  >40 publications with SCNN1B and Cardiovascular Diseases
 Liddle Syndrome Antibodies  >31 publications with SCNN1B and Liddle Syndrome
 Kidney Diseases Antibodies  >30 publications with SCNN1B and Kidney Diseases
 Cystic Fibrosis Antibodies  >25 publications with SCNN1B and Cystic Fibrosis
 Fibrosis Antibodies  >25 publications with SCNN1B and Fibrosis
 Lung Diseases Antibodies  >24 publications with SCNN1B and Lung Diseases
 Pseudohypoaldosteronism Antibodies  >19 publications with SCNN1B and Pseudohypoaldosteronism
 Inflammation Antibodies  >14 publications with SCNN1B and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >37 publications with SCNN1B and Kidney
 Lung Antibodies  >35 publications with SCNN1B and Lung
 Heart Antibodies  >8 publications with SCNN1B and Heart
 Intestine Antibodies  >5 publications with SCNN1B and Intestine
 Placenta Antibodies  >4 publications with SCNN1B and Placenta
 Brain Antibodies  >2 publications with SCNN1B and Brain
 Trachea Antibodies  >2 publications with SCNN1B and Trachea
 Mammary Gland Antibodies  >2 publications with SCNN1B and Mammary Gland
 Uterus Antibodies  >2 publications with SCNN1B and Uterus
 Eye Antibodies  >1 publications with SCNN1B and Eye
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