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ANG1 elisa kit :: Porcine Angiotensin 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS016917 ANG1 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Angiotensin 1 (ANG1), ELISA Kit

 Also Known As   

Porcine Angiotensin 1 ELISA Kit

 Product Gene Name   

ANG1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 8; NC_000008.10 (108261710..108510254, complement). Location: 8q23.1
 OMIM    601667
 3D Structure    ModBase 3D Structure for Q15389
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 Species Reactivity    Porcine
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ANG1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ANG1 purchase    MBS016917 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Angiotensin 1 (ANG1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ANG1. The ELISA analytical biochemical technique of the MBS016917 kit is based on ANG1 antibody-ANG1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ANG1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ANG1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ANG1. It may not necessarily be applicable to this product.
 NCBI GI #    315434240
 NCBI GeneID    284
 NCBI Accession #    NP_001186788.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001199859.1 [Other Products]
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 UniProt Primary Accession #    Q15389 [Other Products]
 UniProt Secondary Accession #    Q5HYA0 [Other Products]
 UniProt Related Accession #    Q15389 [Other Products]
 Molecular Weight    57,513 Da
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 NCBI Official Full Name    angiopoietin-1 isoform 2
 NCBI Official Synonym Full Names    angiopoietin 1
 NCBI Official Symbol    ANGPT1 [Similar Products]
 NCBI Official Synonym Symbols   
AGP1; AGPT; ANG1
[Similar Products]
 NCBI Protein Information    angiopoietin-1; ANG-1
 UniProt Protein Name    Angiopoietin-1
 Protein Family    Angiogenin
 UniProt Gene Name    ANGPT1 [Similar Products]
 UniProt Synonym Gene Names    KIAA0003; ANG-1 [Similar Products]
 UniProt Entry Name    ANGP1_HUMAN
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 NCBI Summary for ANG1    Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]
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 UniProt Comments for ANG1    ANGPT1: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8q23.1

Cellular Component: extracellular space; microvillus; extracellular region; plasma membrane; lipid raft

Molecular Function: receptor tyrosine kinase binding

Biological Process: transmembrane receptor protein tyrosine kinase activation (dimerization); positive regulation of cell adhesion; positive regulation of receptor internalization; negative regulation of protein import into nucleus; negative regulation of cell adhesion; positive chemotaxis; negative regulation of protein amino acid phosphorylation; hemopoiesis; negative regulation of neuron apoptosis; cell differentiation; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of endothelial cell proliferation; Tie receptor signaling pathway; in utero embryonic development; positive regulation of blood vessel endothelial cell migration; positive regulation of peptidyl-serine phosphorylation; cell-substrate adhesion; negative regulation of cytokine secretion during immune response; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; heparin biosynthetic process; positive regulation of protein ubiquitination; regulation of protein binding; negative regulation of vascular permeability; regulation of tumor necrosis factor production; sprouting angiogenesis; regulation of satellite cell proliferation; blood coagulation; leukocyte migration; negative regulation of apoptosis
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 Research Articles on ANG1    1. ligand-independent dimerization of Tie2 is essential for a strong response upon stimulation with high dose Ang1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ANG1 elisa kitPathways associated with ANG1 elisa kit
 Reference Product  PubMed Publications
 ANGPT2 elisa kit  >786 publications with ANG1 and ANGPT2
 VEGFA elisa kit  >109 publications with ANG1 and VEGFA
 TEK elisa kit  >63 publications with ANG1 and TEK
 MMP2 elisa kit  >5 publications with ANG1 and MMP2
 ETS1 elisa kit  >2 publications with ANG1 and ETS1
 PIK3CA elisa kit  >2 publications with ANG1 and PIK3CA
 PIK3CB elisa kit  >1 publications with ANG1 and PIK3CB
 Products by Pathway  Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
 Tie2 Signaling Pathway antibodies  Tie2 Signaling Pathway Diagram
Diseases associated with ANG1 elisa kitOrgans/Tissues associated with ANG1 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >354 publications with ANG1 and Neoplasms
 Cardiovascular Diseases Antibodies  >278 publications with ANG1 and Cardiovascular Diseases
 Inflammation Antibodies  >179 publications with ANG1 and Inflammation
 Nervous System Diseases Antibodies  >119 publications with ANG1 and Nervous System Diseases
 Heart Diseases Antibodies  >109 publications with ANG1 and Heart Diseases
 Necrosis Antibodies  >96 publications with ANG1 and Necrosis
 Hypertension Antibodies  >89 publications with ANG1 and Hypertension
 Kidney Diseases Antibodies  >62 publications with ANG1 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >55 publications with ANG1 and Neoplasms, Experimental
 Edema Antibodies  >54 publications with ANG1 and Edema
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >1369 publications with ANG1 and Vascular
 Blood Antibodies  >950 publications with ANG1 and Blood
 Muscle Antibodies  >282 publications with ANG1 and Muscle
 Embryonic Tissue Antibodies  >207 publications with ANG1 and Embryonic Tissue
 Bone Antibodies  >179 publications with ANG1 and Bone
 Heart Antibodies  >178 publications with ANG1 and Heart
 Brain Antibodies  >146 publications with ANG1 and Brain
 Lung Antibodies  >137 publications with ANG1 and Lung
 Bone Marrow Antibodies  >122 publications with ANG1 and Bone Marrow
 Kidney Antibodies  >104 publications with ANG1 and Kidney
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