NP_112503.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,518 Da
NCBI Official Full Name
aromatase
NCBI Official Synonym Full Names
cytochrome P450 family 19 subfamily A member 1
NCBI Official Synonym Symbols
ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM [Similar Products]
NCBI Protein Information
aromatase
UniProt Protein Name
Aromatase
UniProt Synonym Protein Names
CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase
UniProt Synonym Gene Names
UniProt Entry Name
CP19A_HUMAN
NCBI Summary for ARO
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
UniProt Comments for ARO
CYP19A1: Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Belongs to the cytochrome P450 family.
Protein type: Oxidoreductase; Lipid Metabolism - androgen and estrogen; EC 1.14.14.14
Chromosomal Location of Human Ortholog: 15q21.1
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; membrane
Molecular Function: electron carrier activity; heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxygen binding
Biological Process: androgen metabolic process; estrogen biosynthetic process; negative regulation of chronic inflammatory response; steroid biosynthetic process; steroid metabolic process; sterol metabolic process; xenobiotic metabolic process
Disease: Aromatase Deficiency; Aromatase Excess Syndrome
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Products associated with ARO elisa kit
Pathways associated with ARO elisa kit
Diseases associated with ARO elisa kit
Organs/Tissues associated with ARO elisa kit
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