NP_000006.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,542 Da
NCBI Official Full Name
arylamine N-acetyltransferase 2
NCBI Official Synonym Full Names
N-acetyltransferase 2 (arylamine N-acetyltransferase)
NCBI Protein Information
arylamine N-acetyltransferase 2; arylamide acetylase 2; N-acetyltransferase type 2
UniProt Protein Name
Arylamine N-acetyltransferase 2
UniProt Synonym Protein Names
Arylamide acetylase 2; N-acetyltransferase type 2; NAT-2; Polymorphic arylamine N-acetyltransferase; PNAT
UniProt Synonym Gene Names
UniProt Entry Name
ARY2_HUMAN
NCBI Summary for NAT2
This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008]
UniProt Comments for NAT2
NAT2: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens. Belongs to the arylamine N-acetyltransferase family.
Protein type: Xenobiotic Metabolism - drug metabolism - other enzymes; Acetyltransferase; Secondary Metabolites Metabolism - caffeine; EC 2.3.1.5; Translation
Chromosomal Location of Human Ortholog: 8p22
Cellular Component: cytosol
Molecular Function: arylamine N-acetyltransferase activity
Biological Process: xenobiotic metabolic process
Disease: Acetylation, Slow
Research Articles on NAT2
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Pathways associated with NAT2 elisa kit
Diseases associated with NAT2 elisa kit
Organs/Tissues associated with NAT2 elisa kit
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