NP_001878.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Related Accession #
Molecular Weight
28,023 Da
NCBI Official Full Name
beta-crystallin B1
NCBI Official Synonym Full Names
crystallin, beta B1
NCBI Protein Information
beta-crystallin B1; beta-B1 crystallin; eye lens structural protein
UniProt Protein Name
Beta-crystallin B1
UniProt Synonym Protein Names
Beta-B1 crystallin
UniProt Entry Name
CRBB1_HUMAN
NCBI Summary for CRYBB1
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, undergoes extensive cleavage at its N-terminal extension during lens maturation. It is also a member of a gene cluster with beta-A4, beta-B2, and beta-B3. [provided by RefSeq, Jul 2008]
UniProt Comments for CRYBB1
CRYBB1: a major structural protein of the eye lens. A member of the beta/gamma-crystallin family. Specific cleavages in the N-terminal arm occur during lens maturation and give rise to truncated forms, leading to impaired oligomerization and protein insolubilization. The protease responsible for this partial degradation could be calpain II.
Chromosomal Location of Human Ortholog: 22q12.1
Molecular Function: structural constituent of eye lens
Biological Process: visual perception
Disease: Cataract 17, Multiple Types
Research Articles on CRYBB1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with CRYBB1 elisa kit
Diseases associated with CRYBB1 elisa kit
Organs/Tissues associated with CRYBB1 elisa kit
|