NP_057686.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,416 Da
NCBI Official Full Name
C-C chemokine receptor type 10
NCBI Official Synonym Full Names
chemokine (C-C motif) receptor 10
NCBI Official Synonym Symbols
NCBI Protein Information
C-C chemokine receptor type 10; CCR-10; CC-CKR-10; C-C CKR-10; CC chemokine receptor 10; G protein-coupled receptor 2; G-protein coupled receptor 2
UniProt Protein Name
C-C chemokine receptor type 10
UniProt Synonym Protein Names
G-protein coupled receptor 2
UniProt Synonym Gene Names
UniProt Entry Name
CCR10_HUMAN
NCBI Summary for CCR10
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]
UniProt Comments for CCR10
CCR10: Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1
Chromosomal Location of Human Ortholog: 17q21.1-q21.3
Cellular Component: cell surface; integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; C-C chemokine receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; immune response; chemotaxis
Research Articles on CCR10
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Products associated with CCR10 elisa kit
Pathways associated with CCR10 elisa kit
Diseases associated with CCR10 elisa kit
Organs/Tissues associated with CCR10 elisa kit
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