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C-MET elisa kit :: Porcine C-Met Proto-Oncogene Protein ELISA Kit

Scan QR to view Datasheet Catalog #    MBS008644 C-MET elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C-Met Proto-Oncogene Protein, ELISA Kit

 Also Known As   

Porcine C-Met Proto-Oncogene Protein ELISA Kit

 Product Gene Name   

C-MET elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 14; NC_006596.3 (55626435..55709875). Location: chromosome: 14
 3D Structure    ModBase 3D Structure for Q75ZY9
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 Species Reactivity    Porcine
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of C-MET elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for C-MET purchase    MBS008644 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the C-Met Proto-Oncogene Protein, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing C-MET. The ELISA analytical biochemical technique of the MBS008644 kit is based on C-MET antibody-C-MET antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect C-MET antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, C-MET. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for C-MET. It may not necessarily be applicable to this product.
 NCBI GI #    25815188
 NCBI GeneID    403438
 NCBI Accession #    BAC41197.1 [Other Products]
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 UniProt Primary Accession #    Q75ZY9 [Other Products]
 UniProt Secondary Accession #    A0M8U9 [Other Products]
 UniProt Related Accession #    Q75ZY9 [Other Products]
 Molecular Weight    154,637 Da
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 NCBI Official Full Name    c-Met
 NCBI Official Symbol    MET [Similar Products]
 NCBI Official Synonym Symbols   
c-Met
[Similar Products]
 NCBI Protein Information    hepatocyte growth factor receptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase
 UniProt Protein Name    Hepatocyte growth factor receptor
 UniProt Synonym Protein Names   
HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met
 UniProt Gene Name    MET [Similar Products]
 UniProt Synonym Gene Names    HGF receptor; SF receptor [Similar Products]
 UniProt Entry Name    MET_CANFA
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 UniProt Comments for C-MET    Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells

By similarity. Ref.4

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme regulation: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity

By similarity.

Subunit structure: Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1357, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10

By similarity.

Subcellular location: Membrane; Single-pass type I membrane protein

By similarity.

Domain: The kinase domain is involved in SPSB1 binding

By similarity.The beta-propeller Sema domain mediates binding to HGF

By similarity.

Post-translational modification: Autophosphorylated in response to ligand binding on Tyr-1235 and Tyr-1236 in the kinase domain leading to further phosphorylation of Tyr-1350 and Tyr-1357 in the C-terminal multifunctional docking site

By similarity.Dephosphorylated by PTPRJ at Tyr-1350 and Tyr-1366

By similarity.Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation

By similarity.

Sequence similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family.Contains 3 IPT/TIG domains.Contains 1 protein kinase domain.Contains 1 Sema domain.
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 Research Articles on C-MET    1. NFAT-dependent gene transcription is required for hepatocyte growth factor-induced cell scattering.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with C-MET elisa kitPathways associated with C-MET elisa kit
 Reference Product  PubMed Publications
 HGF elisa kit  >2403 publications with C-MET and HGF
 EGF elisa kit  >256 publications with C-MET and EGF
 CTNNB1 elisa kit  >175 publications with C-MET and CTNNB1
 GRB2 elisa kit  >114 publications with C-MET and GRB2
 GAB1 elisa kit  >89 publications with C-MET and GAB1
 CBL elisa kit  >57 publications with C-MET and CBL
 PIK3CA elisa kit  >50 publications with C-MET and PIK3CA
 VEGFA elisa kit  >43 publications with C-MET and VEGFA
 SH3KBP1 elisa kit  >3 publications with C-MET and SH3KBP1
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
Diseases associated with C-MET elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >11369 publications with C-MET and Neoplasms
 Cardiovascular Diseases Antibodies  >7728 publications with C-MET and Cardiovascular Diseases
 Carcinoma Antibodies  >3844 publications with C-MET and Carcinoma
 Inflammation Antibodies  >2013 publications with C-MET and Inflammation
 Liver Diseases Antibodies  >1760 publications with C-MET and Liver Diseases
 Adenocarcinoma Antibodies  >1747 publications with C-MET and Adenocarcinoma
 Schizophrenia Antibodies  >1601 publications with C-MET and Schizophrenia
 Kidney Diseases Antibodies  >1551 publications with C-MET and Kidney Diseases
 Breast Neoplasms Antibodies  >1472 publications with C-MET and Breast Neoplasms
 Lung Neoplasms Antibodies  >1205 publications with C-MET and Lung Neoplasms
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