NP_001131140.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
222,658 Da
NCBI Official Full Name
CASP8-associated protein 2
NCBI Official Synonym Full Names
caspase 8 associated protein 2
NCBI Protein Information
CASP8-associated protein 2; human FLASH; FLASH homolog RIP25; FLICE associated huge; CASP8 associated protein 2; FLICE-associated huge protein
UniProt Protein Name
CASP8-associated protein 2
UniProt Synonym Protein Names
FLICE-associated huge protein
UniProt Synonym Gene Names
UniProt Entry Name
C8AP2_HUMAN
NCBI Summary for CASP8AP2
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008]
UniProt Comments for CASP8AP2
CASP8AP2: Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF- kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.
Protein type: Nuclear receptor co-regulator; Apoptosis
Chromosomal Location of Human Ortholog: 6q15
Cellular Component: PML body; mitochondrion; cytoplasm; nucleus
Molecular Function: protein binding; DNA binding; death receptor binding; SUMO polymer binding; apoptotic protease activator activity; caspase activator activity; transcription corepressor activity
Biological Process: caspase activation; transcription, DNA-dependent; induction of apoptosis via death domain receptors; regulation of transcription, DNA-dependent; cell cycle; signal transduction
Research Articles on CASP8AP2
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Products associated with CASP8AP2 elisa kit
Pathways associated with CASP8AP2 elisa kit
Diseases associated with CASP8AP2 elisa kit
Organs/Tissues associated with CASP8AP2 elisa kit
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