NP_004258.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,787 Da
NCBI Official Full Name
carbohydrate sulfotransferase 2
NCBI Official Synonym Full Names
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
NCBI Official Synonym Symbols
C6ST; GST2; GST-2; Gn6ST-1; HEL-S-75; glcNAc6ST-1 [Similar Products]
NCBI Protein Information
carbohydrate sulfotransferase 2; epididymis secretory protein Li 75; N-acetylglucosamine 6-O-sulfotransferase 1; carbohydrate (chondroitin 6/keratan) sulfotransferase 2; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2
UniProt Protein Name
Carbohydrate sulfotransferase 2
UniProt Synonym Protein Names
Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2; GST-2; N-acetylglucosamine 6-O-sulfotransferase 1; GlcNAc6ST-1; Gn6ST-1
UniProt Synonym Gene Names
UniProt Entry Name
CHST2_HUMAN
NCBI Summary for CHST2
This locus encodes a sulfotransferase protein. The encoded enzyme catalyzes the sulfation of a nonreducing N-acetylglucosamine residue, and may play a role in biosynthesis of 6-sulfosialyl Lewis X antigen. [provided by RefSeq, Aug 2011]
UniProt Comments for CHST2
CHST2: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains. Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily. 2 isoforms of the human protein are produced by alternative initiation.
Protein type: Transferase; Glycan Metabolism - keratan sulfate biosynthesis; Membrane protein, integral; EC 2.8.2.-
Chromosomal Location of Human Ortholog: 3q24
Cellular Component: Golgi membrane; intrinsic to Golgi membrane; integral to membrane; trans-Golgi network
Molecular Function: sulfotransferase activity; N-acetylglucosamine 6-O-sulfotransferase activity
Biological Process: keratan sulfate metabolic process; sulfur metabolic process; glycosaminoglycan metabolic process; multicellular organismal development; keratan sulfate biosynthetic process; N-acetylglucosamine metabolic process; carbohydrate metabolic process; pathogenesis; inflammatory response
Research Articles on CHST2
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Products associated with CHST2 elisa kit
Pathways associated with CHST2 elisa kit
Diseases associated with CHST2 elisa kit
Organs/Tissues associated with CHST2 elisa kit
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