NP_033941.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
31,595 Da
NCBI Official Full Name
caspase-6
NCBI Official Synonym Full Names
caspase 6
NCBI Protein Information
caspase-6; CASP-6; apoptotic protease Mch-2
UniProt Protein Name
Caspase-6
UniProt Synonym Protein Names
Apoptotic protease Mch-2
UniProt Synonym Gene Names
UniProt Entry Name
CASP6_MOUSE
NCBI Summary for CASPASE-6
This gene encodes a member of the cysteine proteases that plays important roles in regulating apoptosis and neurodegeneration. The encoded protein is involved in the transmission of pain and axonal degeneration. Genetic deletion of this gene in mice results in the delay of axon pruning and protects from axon degeneration. [provided by RefSeq, Apr 2015]
UniProt Comments for CASPASE-6
CASP6: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Activation is suppressed by phosphorylation at Ser-257. Belongs to the peptidase C14A family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.22.59; Apoptosis; Protease
Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus
Molecular Function: peptidase activity; identical protein binding; protein binding; hydrolase activity; endopeptidase activity; cysteine-type peptidase activity
Biological Process: regulation of apoptosis; response to hydrogen peroxide; positive regulation of apoptosis; positive regulation of retinal cell programmed cell death; response to cytokine stimulus; positive regulation of neuron apoptosis; acute inflammatory response to non-antigenic stimulus; response to glucose stimulus; proteolysis; response to iron ion
Research Articles on CASPASE-6
Precautions
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Pathways associated with CASPASE-6 elisa kit
Diseases associated with CASPASE-6 elisa kit
Organs/Tissues associated with CASPASE-6 elisa kit
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