NP_000387.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,966 Da
NCBI Official Full Name
cathepsin K preproprotein
NCBI Official Synonym Full Names
cathepsin K
NCBI Official Synonym Symbols
CTSO; PKND; PYCD; CTS02; CTSO1; CTSO2 [Similar Products]
NCBI Protein Information
cathepsin K; cathepsin O; cathepsin X; cathepsin O1; cathepsin O2
UniProt Protein Name
Cathepsin K
UniProt Synonym Protein Names
Cathepsin O; Cathepsin O2; Cathepsin X
UniProt Synonym Gene Names
UniProt Entry Name
CATK_HUMAN
NCBI Summary for CTSK
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]
UniProt Comments for CTSK
CTSK: Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Defects in CTSK are the cause of pycnodysostosis (PKND). PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature. Belongs to the peptidase C1 family.
Protein type: Protease; EC 3.4.22.38
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: extracellular space; extracellular region
Molecular Function: collagen binding; protein binding; proteoglycan binding; fibronectin binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity
Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; intramembranous ossification; proteolysis involved in cellular protein catabolic process; toll-like receptor signaling pathway; innate immune response; proteolysis; bone resorption
Disease: Pycnodysostosis
Research Articles on CTSK
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Pathways associated with CTSK elisa kit
Diseases associated with CTSK elisa kit
Organs/Tissues associated with CTSK elisa kit
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