NP_037423.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
160,884 Da
NCBI Official Full Name
cleavage and polyadenylation specificity factor subunit 1
NCBI Official Synonym Full Names
cleavage and polyadenylation specific factor 1, 160kDa
NCBI Protein Information
cleavage and polyadenylation specificity factor subunit 1; CPSF 160 kDa subunit; cleavage and polyadenylation specificity factor 160 kDa subunit
UniProt Protein Name
Cleavage and polyadenylation specificity factor subunit 1
UniProt Synonym Protein Names
Cleavage and polyadenylation specificity factor 160 kDa subunit; CPSF 160 kDa subunit
UniProt Synonym Gene Names
UniProt Entry Name
CPSF1_HUMAN
NCBI Summary for CPSF1
Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]
UniProt Comments for CPSF1
CPSF1: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction. Belongs to the CPSF1 family.
Protein type: RNA splicing; RNA-binding
Chromosomal Location of Human Ortholog: 8q24.23
Cellular Component: nucleoplasm; mRNA cleavage and polyadenylation specificity factor complex
Molecular Function: protein binding; mRNA 3'-UTR binding
Biological Process: transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; mRNA export from nucleus; RNA splicing; gene expression; mRNA polyadenylation; mRNA 3'-end processing; termination of RNA polymerase II transcription; mRNA cleavage
Research Articles on CPSF1
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Pathways associated with CPSF1 elisa kit
Diseases associated with CPSF1 elisa kit
Organs/Tissues associated with CPSF1 elisa kit
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