NP_061119.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,058 Da
NCBI Official Full Name
core histone macro-H2A.2
NCBI Official Synonym Full Names
H2A histone family, member Y2
NCBI Official Synonym Symbols
NCBI Protein Information
core histone macro-H2A.2; mH2A2; histone macroH2A2; core histone macroH2A2.2
UniProt Protein Name
Core histone macro-H2A.2
UniProt Synonym Gene Names
UniProt Entry Name
H2AW_HUMAN
NCBI Summary for H2AFY2
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and may participate in stable X chromosome inactivation. [provided by RefSeq, Aug 2015]
UniProt Comments for H2AFY2
H2AFY2: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 10q22.1
Cellular Component: nucleoplasm; ESC/E(Z) complex; nuclear chromatin; Barr body; nucleosome; nucleus
Molecular Function: chromatin DNA binding; protein heterodimerization activity
Biological Process: nucleosome assembly; negative regulation of gene expression, epigenetic; dosage compensation; regulation of cell growth; negative regulation of transcription from RNA polymerase II promoter; brain development; chromatin modification
Research Articles on H2AFY2
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Pathways associated with H2AFY2 elisa kit
Diseases associated with H2AFY2 elisa kit
Organs/Tissues associated with H2AFY2 elisa kit
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