AAH19077.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,764 Da
NCBI Official Full Name
Galactose-3-O-sulfotransferase 1
NCBI Official Synonym Full Names
galactose-3-O-sulfotransferase 1
NCBI Official Synonym Symbols
NCBI Protein Information
galactosylceramide sulfotransferase
UniProt Protein Name
Galactosylceramide sulfotransferase
UniProt Synonym Protein Names
3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase; 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase; Cerebroside sulfotransferase
UniProt Synonym Gene Names
UniProt Entry Name
G3ST1_HUMAN
NCBI Summary for GAL3ST1
Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. This gene encodes galactosylceramide sulfotransferase, which catalyzes the sulfation of membrane glycolipids including the final step in the synthesis of sulfatide, a major lipid component of the myelin sheath. This gene exhibits elevated expression in ovarian epithelial carcinoma and the encoded enzyme exhibits elevated activity in renal cell carcinoma. Mutations in this gene may be associated with reduced insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
UniProt Comments for GAL3ST1
GAL3ST1: Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes. Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro). Belongs to the galactose-3-O-sulfotransferase family.
Protein type: Membrane protein, integral; Transferase; Lipid Metabolism - sphingolipid; EC 2.8.2.11
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: Golgi membrane; integral to plasma membrane; membrane
Molecular Function: galactosylceramide sulfotransferase activity; sulfotransferase activity
Biological Process: galactosylceramide biosynthetic process; myelination; protein amino acid N-linked glycosylation; spermatogenesis
Research Articles on GAL3ST1
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Products associated with GAL3ST1 elisa kit
Pathways associated with GAL3ST1 elisa kit
Diseases associated with GAL3ST1 elisa kit
Organs/Tissues associated with GAL3ST1 elisa kit
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