AAD00826.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51,023 Da
NCBI Official Full Name
hepatocyte nuclear factor-6 alpha
NCBI Official Synonym Full Names
one cut homeobox 1
NCBI Protein Information
hepatocyte nuclear factor 6; one cut domain family member 1; hepatocyte nuclear factor 6, alpha
UniProt Protein Name
Hepatocyte nuclear factor 6
UniProt Synonym Protein Names
One cut domain family member 1; One cut homeobox 1
UniProt Synonym Gene Names
UniProt Entry Name
HNF6_HUMAN
NCBI Summary for HNF6alpha
This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
UniProt Comments for HNF6alpha
ONECUT1: Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. Belongs to the CUT homeobox family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 15q21.3
Cellular Component: nucleus
Molecular Function: DNA binding
Biological Process: spleen development; cell fate commitment; transcription, DNA-dependent; regulation of cell-matrix adhesion; system development; glucose metabolic process; liver development; endocrine pancreas development; regulation of transcription, DNA-dependent; B cell differentiation; epithelial cell development; cilium biogenesis; positive regulation of transcription from RNA polymerase II promoter; cell differentiation; negative regulation of transforming growth factor beta receptor signaling pathway; endoderm development; positive regulation of cell migration
Research Articles on HNF6alpha
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Pathways associated with HNF6alpha elisa kit
Diseases associated with HNF6alpha elisa kit
Organs/Tissues associated with HNF6alpha elisa kit
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