P47125.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,775 Da
NCBI Official Full Name
Indoleamine 2,3-dioxygenase
NCBI Protein Information
Bna2p
UniProt Protein Name
Indoleamine 2,3-dioxygenase
UniProt Synonym Protein Names
Biosynthesis of nicotinic acid protein 2
UniProt Synonym Gene Names
UniProt Entry Name
I23O_YEAST
UniProt Comments for IDO
Function: Catalyzes the first step in tryptophan catabolism in order to supply de novo nicotinamide adenine dinucleotide (NAD+) via the kynurenine pathway. Plays a role in the cellular response to telomere uncapping.
Catalytic activity: D-tryptophan + O2 = N-formyl-D-kynurenine.L-tryptophan + O2 = N-formyl-L-kynurenine.
Cofactor: Binds 1 heme group per subunit
By similarity.
Pathway: Cofactor biosynthesis; NAD(+) biosynthesis. Ref.4
Induction: Expression is mediated by the AFT2, HCM1, and SUM1 transcription factors. Up-regulated in absence of NPT1.
Miscellaneous: Present with 149 molecules/cell in log phase SD medium.
Sequence similarities: Belongs to the indoleamine 2,3-dioxygenase family.
Biophysicochemical propertiesKinetic parameters:KM=412 µM for L-tryptophanKM=9.2 mM for D-tryptophan
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Products associated with IDO elisa kit
Pathways associated with IDO elisa kit
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