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KL elisa kit :: Porcine Klotho ELISA Kit

Scan QR to view Datasheet Catalog #    MBS020147 KL elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Klotho, ELISA Kit

 Also Known As   

Porcine Klotho ELISA Kit

 Product Gene Name   

KL elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 13; NC_000013.10 (33590571..33640282). Location: 13q12
 OMIM    211900
 3D Structure    ModBase 3D Structure for Q9UEF7
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 Species Reactivity    Porcine
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of KL elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for KL purchase    MBS020147 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Klotho, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KL. The ELISA analytical biochemical technique of the MBS020147 kit is based on KL antibody-KL antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KL antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KL. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for KL. It may not necessarily be applicable to this product.
 NCBI GI #    2618596
 NCBI GeneID    9365
 NCBI Accession #    BAA23382.1 [Other Products]
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 UniProt Primary Accession #    Q9UEF7 [Other Products]
 UniProt Secondary Accession #    Q5VZ95; Q96KV5; Q96KW5; Q9UEI9; Q9Y4F0 [Other Products]
 UniProt Related Accession #    Q9UEF7 [Other Products]
 Molecular Weight    116,181 Da
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 NCBI Official Full Name    klotho
 NCBI Official Synonym Full Names    klotho
 NCBI Official Symbol    KL [Similar Products]
 NCBI Protein Information    klotho
 UniProt Protein Name    Klotho
 Protein Family    Klotho
 UniProt Gene Name    KL [Similar Products]
 UniProt Entry Name    KLOT_HUMAN
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 NCBI Summary for KL    This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KL    Klotho: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1. Defects in KL are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC). A severe metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Some patients manifest recurrent, transient, painful swellings of the long bones associated with the radiographic findings of periosteal reaction and cortical hyperostosis and absence of skin involvement. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.2.1.31; Hydrolase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q12

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; extracellular region; integral to membrane

Molecular Function: vitamin D binding; signal transducer activity; beta-glucuronidase activity; fibroblast growth factor binding; beta-glucosidase activity; hormone activity; fibroblast growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; calcium ion homeostasis; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; carbohydrate metabolic process; energy reserve metabolic process; insulin receptor signaling pathway; innate immune response; positive regulation of bone mineralization; acute inflammatory response; aging

Disease: Tumoral Calcinosis, Hyperphosphatemic, Familial
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 Research Articles on KL    1. loss of Klotho may contribute to kidney injury by releasing the repression of pathogenic Wnt/beta-catenin signaling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KL elisa kitPathways associated with KL elisa kit
 Reference Product  PubMed Publications
 FGF23 elisa kit  >28 publications with KL and FGF23
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
Diseases associated with KL elisa kitOrgans/Tissues associated with KL elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >287 publications with KL and Neoplasms
 Pneumonia Antibodies  >188 publications with KL and Pneumonia
 Skin Diseases Antibodies  >110 publications with KL and Skin Diseases
 Pulmonary Fibrosis Antibodies  >106 publications with KL and Pulmonary Fibrosis
 Inflammation Antibodies  >76 publications with KL and Inflammation
 Heart Diseases Antibodies  >70 publications with KL and Heart Diseases
 Death Antibodies  >62 publications with KL and Death
 Drug Toxicity Antibodies  >60 publications with KL and Drug Toxicity
 Lung Injury Antibodies  >56 publications with KL and Lung Injury
 Kidney Diseases Antibodies  >49 publications with KL and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >268 publications with KL and Bone
 Brain Antibodies  >216 publications with KL and Brain
 Kidney Antibodies  >111 publications with KL and Kidney
 Connective Tissue Antibodies  >56 publications with KL and Connective Tissue
 Spleen Antibodies  >34 publications with KL and Spleen
 Eye Antibodies  >31 publications with KL and Eye
 Intestine Antibodies  >19 publications with KL and Intestine
 Parathyroid Antibodies  >17 publications with KL and Parathyroid
 Ganglia Antibodies  >13 publications with KL and Ganglia
 Pancreas Antibodies  >12 publications with KL and Pancreas
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