NP_640341.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,859 Da
NCBI Official Full Name
lipase member H
NCBI Official Synonym Full Names
lipase, member H
NCBI Official Synonym Symbols
AH; LAH2; ARWH2; HYPT7; LPDLR; PLA1B; mPA-PLA1 [Similar Products]
NCBI Protein Information
lipase member H; lipase H; mPA-PLA1 alpha; phospholipase A1 member B; LPD lipase-related protein; membrane-bound phosphatidic acid-selective phospholipase A1; membrane-associated phosphatidic acid-selective phospholipase A1-alpha
UniProt Protein Name
Lipase member H
UniProt Synonym Protein Names
LPD lipase-related protein; Membrane-associated phosphatidic acid-selective phospholipase A1-alpha; mPA-PLA1 alpha; Phospholipase A1 member B
UniProt Synonym Gene Names
UniProt Entry Name
LIPH_HUMAN
NCBI Summary for LIPH
This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. [provided by RefSeq, Jul 2008]
UniProt Comments for LIPH
LIPH: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). Defects in LIPH are the cause of hypotrichosis type 7 (HYPT7); also known as alopecia universalis congenita Mari type. A condition characterized by the presence of less than the normal amount of hair. Affected individuals have sparse or absent scalp, axillary and body hair and sparse eyebrows and eyelashes. Defects in LIPH are the cause of woolly hair autosomal recessive type 2 (ARWH2). A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals may present with hypotrichosis. Belongs to the AB hydrolase superfamily. Lipase family.
Protein type: Secreted, signal peptide; EC 3.1.1.-; Secreted; Phospholipase
Chromosomal Location of Human Ortholog: 3q27
Cellular Component: extracellular space; plasma membrane
Molecular Function: heparin binding; phospholipase activity
Biological Process: lipid catabolic process
Disease: Hypotrichosis 7
Research Articles on LIPH
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Products associated with LIPH elisa kit
Diseases associated with LIPH elisa kit
Organs/Tissues associated with LIPH elisa kit
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