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LRP5 elisa kit :: Porcine Low Density Lipoprotein Receptor Related Protein 5 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS097490 LRP5 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Low Density Lipoprotein Receptor Related Protein 5 (LRP5), ELISA Kit

 Also Known As   

Porcine Low Density Lipoprotein Receptor Related Protein 5 ELISA Kit

 Product Gene Name   

LRP5 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    144750
 3D Structure    ModBase 3D Structure for O75197
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 Species Reactivity    Porcine
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of LRP5 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for LRP5 purchase    MBS097490 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Low Density Lipoprotein Receptor Related Protein 5 (LRP5) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing LRP5. The ELISA analytical biochemical technique of the MBS097490 kit is based on LRP5 antibody-LRP5 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LRP5 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LRP5. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for LRP5. It may not necessarily be applicable to this product.
 NCBI GI #    119709832
 NCBI GeneID    4041
 NCBI Accession #    NP_002326.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002335.3 [Other Products]
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 UniProt Primary Accession #    O75197 [Other Products]
 UniProt Secondary Accession #    Q96TD6; Q9UES7; Q9UP66 [Other Products]
 UniProt Related Accession #    O75197 [Other Products]
 Molecular Weight    179,145 Da
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 NCBI Official Full Name    low-density lipoprotein receptor-related protein 5 isoform 1
 NCBI Official Synonym Full Names    low density lipoprotein receptor-related protein 5
 NCBI Official Symbol    LRP5 [Similar Products]
 NCBI Official Synonym Symbols   
HBM; LR3; OPS; EVR1; EVR4; LRP7; OPPG; BMND1; LRP-5; OPTA1; VBCH2
[Similar Products]
 NCBI Protein Information    low-density lipoprotein receptor-related protein 5; low density lipoprotein receptor-related protein 7
 UniProt Protein Name    Low-density lipoprotein receptor-related protein 5
 Protein Family    Low-density lipoprotein receptor-related protein
 UniProt Gene Name    LRP5 [Similar Products]
 UniProt Synonym Gene Names    LR3; LRP7; LRP-5 [Similar Products]
 UniProt Entry Name    LRP5_HUMAN
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 NCBI Summary for LRP5    This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
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 UniProt Comments for LRP5    LRP5: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation. Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling. Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts with FZD8; the interaction is formed on WNT-binding and signaling. Interacts (via the phosphorylated PPPSP motif domains) with AXIN1; the interaction prevents inhibition of beta-catenin phosphorylation and signaling and is enhanced in the presence of GSK3B and WNT1 or WNT3A. Interacts (via beta-propeller regions 3 and 4) with DKK1; the interaction, enhanced by MESD and/or KREMEN, inhibits beta-catenin signaling by preventing GSK3-mediated phosphorylation of the PPPSP motifs and subsequent, AXIN1 binding. Interacts with MESD; the interaction prevents the formation of LRP5 aggregates, targets LRP5 to the plasma membrane and, when complexed with KREMEN2, increases DKK1 binding. Interacts with CSNK1E. Interacts with SOST; the interaction antagonizes canonical Wnt signaling. Interacts with APCDD1. Widely expressed, with the highest level of expression in the liver and in aorta. Belongs to the LDLR family.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: mitochondrion; endoplasmic reticulum; plasma membrane; integral to membrane; receptor complex

Molecular Function: Wnt-protein binding; Wnt receptor activity; protein binding; toxin transporter activity; coreceptor activity

Biological Process: response to peptide hormone stimulus; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; Wnt receptor signaling pathway through beta-catenin; bone remodeling; anatomical structure regression; regulation of apoptosis; anterior/posterior pattern formation; regulation of blood pressure; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; negative regulation of osteoblast differentiation; cell migration involved in gastrulation; embryonic limb morphogenesis; cholesterol metabolic process; Wnt receptor signaling pathway; positive regulation of mitosis; regulation of bone remodeling; endocytosis; gastrulation with mouth forming second; osteoblast development; bone marrow development; glucose catabolic process; cholesterol homeostasis; embryonic retina morphogenesis in camera-type eye; positive regulation of osteoblast proliferation; positive regulation of fat cell differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; retina morphogenesis in camera-type eye

Disease: Osteoporosis-pseudoglioma Syndrome; Van Buchem Disease, Type 2; Osteopetrosis, Autosomal Dominant 1; Exudative Vitreoretinopathy 1; Exudative Vitreoretinopathy 4; Bone Mineral Density Quantitative Trait Locus 1; Osteoporosis; Endosteal Hyperostosis, Autosomal Dominant
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 Research Articles on LRP5    1. LRP5 negatively regulates differentiation of monocytes through abrogation of Wnt signaling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LRP5 elisa kitPathways associated with LRP5 elisa kit
 Reference Product  PubMed Publications
 CTNNB1 elisa kit  >305 publications with LRP5 and CTNNB1
 DKK1 elisa kit  >114 publications with LRP5 and DKK1
 FZD4 elisa kit  >51 publications with LRP5 and FZD4
 WNT1 elisa kit  >47 publications with LRP5 and WNT1
 WNT5A elisa kit  >37 publications with LRP5 and WNT5A
 WNT7B elisa kit  >16 publications with LRP5 and WNT7B
 FZD1 elisa kit  >14 publications with LRP5 and FZD1
 AXIN1 elisa kit  >13 publications with LRP5 and AXIN1
 FZD8 elisa kit  >4 publications with LRP5 and FZD8
 CDH2 elisa kit  >1 publications with LRP5 and CDH2
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 MicroRNAs In Cardiomyocyte Hypertrophy Pathway antibodies  MicroRNAs In Cardiomyocyte Hypertrophy Pathway Diagram
 N-cadherin Signaling Events Pathway antibodies  N-cadherin Signaling Events Pathway Diagram
 RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway antibodies  RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By WNT In Cancer Pathway antibodies  Signaling By WNT In Cancer Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 TCF Dependent Signaling In Response To WNT Pathway antibodies  TCF Dependent Signaling In Response To WNT Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram
 Wnt Signaling Pathway And Pluripotency antibodies  Wnt Signaling Pathway And Pluripotency Diagram
Diseases associated with LRP5 elisa kitOrgans/Tissues associated with LRP5 elisa kit
 Disease Name  Pubmed Publications
 Osteoporosis Antibodies  >242 publications with LRP5 and Osteoporosis
 Fractures, Bone Antibodies  >70 publications with LRP5 and Fractures, Bone
 Osteoporosis-pseudoglioma syndrome Antibodies  >46 publications with LRP5 and Osteoporosis-pseudoglioma syndrome
 Disease Models, Animal Antibodies  >41 publications with LRP5 and Disease Models, Animal
 Nervous System Diseases Antibodies  >29 publications with LRP5 and Nervous System Diseases
 Necrosis Antibodies  >18 publications with LRP5 and Necrosis
 Inflammation Antibodies  >14 publications with LRP5 and Inflammation
 Brain Diseases Antibodies  >14 publications with LRP5 and Brain Diseases
 Heart Diseases Antibodies  >14 publications with LRP5 and Heart Diseases
 Exudative Vitreoretinopathy 4 Antibodies  >13 publications with LRP5 and Exudative Vitreoretinopathy 4
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >449 publications with LRP5 and Bone
 Connective Tissue Antibodies  >109 publications with LRP5 and Connective Tissue
 Eye Antibodies  >53 publications with LRP5 and Eye
 Vascular Antibodies  >46 publications with LRP5 and Vascular
 Embryonic Tissue Antibodies  >37 publications with LRP5 and Embryonic Tissue
 Parathyroid Antibodies  >26 publications with LRP5 and Parathyroid
 Brain Antibodies  >22 publications with LRP5 and Brain
 Liver Antibodies  >21 publications with LRP5 and Liver
 Muscle Antibodies  >19 publications with LRP5 and Muscle
 Intestine Antibodies  >16 publications with LRP5 and Intestine
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