NP_000504.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
40,584 Da
NCBI Official Full Name
medium-wave-sensitive opsin 1
NCBI Official Synonym Full Names
opsin 1 (cone pigments), medium-wave-sensitive
NCBI Official Synonym Symbols
CBD; GCP; GOP; CBBM; COD5; OPN1MW1 [Similar Products]
NCBI Protein Information
medium-wave-sensitive opsin 1; green cone pigment; green-sensitive opsin; photopigment apoprotein; cone dystrophy 5 (X-linked); green cone photoreceptor pigment
UniProt Protein Name
Medium-wave-sensitive opsin 1
UniProt Synonym Protein Names
Green cone photoreceptor pigment; Green-sensitive opsin; GOP
UniProt Synonym Gene Names
UniProt Entry Name
OPSG_HUMAN
NCBI Summary for OPN1MW
This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of deutanopic colorblindness. [provided by RefSeq, Mar 2009]
UniProt Comments for OPN1MW
OPN1MW: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. Defects in OPN1MW are the cause of partial colorblindness deutan series (CBD); also known as deuteranopia. Defects in OPN1MW are a cause of blue cone monochromacy (BCM). A rare X-linked congenital stationary cone dysfunction syndrome characterized by the absence of functional long wavelength-sensitive and medium wavelength-sensitive cones in the retina. Color discrimination is severely impaired from birth, and vision is derived from the remaining preserved blue (S) cones and rod photoreceptors. BCM typically presents with reduced visual acuity, pendular nystagmus, and photophobia. Patients often have myopia. Defects in OPN1MW are a cause of cone dystrophy type 5 (COD5). A X-linked cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies in which some loss of peripheral vision also occurs. Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; photoreceptor activity
Biological Process: positive regulation of cytokinesis; phototransduction, visible light; G-protein coupled receptor protein signaling pathway; visual perception; retinoid metabolic process; protein-chromophore linkage
Disease: Blue Cone Monochromacy; Colorblindness, Partial, Deutan Series
Research Articles on OPN1MW
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