NP_005076.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
215,401 Da
NCBI Official Full Name
nuclear pore complex protein Nup214
NCBI Official Synonym Full Names
nucleoporin 214kDa
NCBI Protein Information
nuclear pore complex protein Nup214; CAN protein, putative oncogene
UniProt Protein Name
Nuclear pore complex protein Nup214
UniProt Synonym Protein Names
214 kDa nucleoporin; Nucleoporin Nup214; Protein CAN
UniProt Synonym Gene Names
UniProt Entry Name
NU214_HUMAN
NCBI Summary for NUP214
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. [provided by RefSeq, Jul 2008]
UniProt Comments for NUP214
NUP214: May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein; Nucleoporin; Nuclear export
Chromosomal Location of Human Ortholog: 9q34.1
Cellular Component: nucleoplasm; focal adhesion; intracellular membrane-bound organelle; nuclear pore; nucleus; cytosol
Molecular Function: protein binding; transporter activity; nucleocytoplasmic transporter activity
Biological Process: viral reproduction; regulation of cell cycle; cytokine and chemokine mediated signaling pathway; mitotic nuclear envelope disassembly; pathogenesis; viral infectious cycle; glucose transport; mRNA export from nucleus; protein import into nucleus; hexose transport; carbohydrate metabolic process; gene expression; viral transcription; mitotic cell cycle; protein export from nucleus; transmembrane transport
Disease: Leukemia, Acute Lymphoblastic
Research Articles on NUP214
Precautions
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Products associated with NUP214 elisa kit
Pathways associated with NUP214 elisa kit
Diseases associated with NUP214 elisa kit
Disease Name |
Pubmed Publications |
Leukemia, Myeloid, Acute Antibodies |
>34 publications with NUP214 and Leukemia, Myeloid, Acute |
Cell Transformation, Neoplastic Antibodies |
>9 publications with NUP214 and Cell Transformation, Neoplastic |
Neoplasms, Experimental Antibodies |
>3 publications with NUP214 and Neoplasms, Experimental |
Death Antibodies |
>3 publications with NUP214 and Death |
Disease Models, Animal Antibodies |
>3 publications with NUP214 and Disease Models, Animal |
Anemia Antibodies |
>2 publications with NUP214 and Anemia |
Neurodegenerative Diseases Antibodies |
>1 publications with NUP214 and Neurodegenerative Diseases |
Hyperplasia Antibodies |
>1 publications with NUP214 and Hyperplasia |
Liver Neoplasms, Experimental Antibodies |
>1 publications with NUP214 and Liver Neoplasms, Experimental |
Precancerous Conditions Antibodies |
>1 publications with NUP214 and Precancerous Conditions |
Organs/Tissues associated with NUP214 elisa kit
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