NP_000737.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11,485 Da
NCBI Official Full Name
neuronal acetylcholine receptor subunit alpha-7 isoform 1
NCBI Official Synonym Full Names
cholinergic receptor nicotinic alpha 7 subunit
NCBI Protein Information
neuronal acetylcholine receptor subunit alpha-7
UniProt Protein Name
Neuronal acetylcholine receptor subunit alpha-7
UniProt Synonym Gene Names
UniProt Entry Name
ACHA7_HUMAN
NCBI Summary for CHRNA7
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
UniProt Comments for CHRNA7
nAChRA7: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 7/CHRNA7 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Channel, cation
Chromosomal Location of Human Ortholog: 15q14
Cellular Component: cell junction; integral to membrane; nicotinic acetylcholine-gated receptor-channel complex; plasma membrane; postsynaptic membrane
Molecular Function: acetylcholine binding; acetylcholine receptor activity; acetylcholine-gated cation channel activity; beta-amyloid binding; chloride channel regulator activity; nicotinic acetylcholine-activated cation-selective channel activity; protein homodimerization activity; toxin binding
Biological Process: activation of MAPK activity; calcium ion transport; cellular calcium ion homeostasis; cognition; ion transport; memory; negative regulation of tumor necrosis factor production; positive regulation of angiogenesis; positive regulation of cell proliferation; response to hypoxia; response to nicotine; signal transduction; synaptic transmission; synaptic transmission, cholinergic
Disease: Chromosome 15q13.3 Deletion Syndrome
Research Articles on CHRNA7
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Products associated with CHRNA7 elisa kit
Pathways associated with CHRNA7 elisa kit
Diseases associated with CHRNA7 elisa kit
Organs/Tissues associated with CHRNA7 elisa kit
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