NP_998776.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,959 Da
NCBI Official Full Name
phosphate carrier protein, mitochondrial isoform b
NCBI Official Synonym Full Names
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
NCBI Protein Information
phosphate carrier protein, mitochondrial; phosphate transport protein
UniProt Protein Name
Phosphate carrier protein, mitochondrial
UniProt Synonym Protein Names
Phosphate transport protein; PTP; Solute carrier family 25 member 3
UniProt Synonym Gene Names
UniProt Entry Name
MPCP_HUMAN
NCBI Summary for PHC
The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated. [provided by RefSeq, Jul 2008]
UniProt Comments for PHC
SLC25A3: Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). Defects in SLC25A3 are a cause of mitochondrial phosphate carrier deficiency (MPCD). MPCD is a fatal disorder of oxidative phosphorylation. Patients have lactic acidosis, hypertrophic cardiomyopathy and muscular hypotonia and die within the first year of life. Belongs to the mitochondrial carrier family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter; Mitochondrial; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12q23
Cellular Component: membrane; mitochondrion; integral to plasma membrane; mitochondrial inner membrane
Molecular Function: phosphate carrier activity; symporter activity; protein complex binding
Biological Process: generation of precursor metabolites and energy; transport
Disease: Mitochondrial Phosphate Carrier Deficiency
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Pathways associated with PHC elisa kit
Diseases associated with PHC elisa kit
Organs/Tissues associated with PHC elisa kit
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