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PTF1alpha elisa kit :: Porcine Pancreas Specific Transcription Factor 1A ELISA Kit

Scan QR to view Datasheet Catalog #    MBS020218 PTF1alpha elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Pancreas Specific Transcription Factor 1A (PTF1alpha), ELISA Kit

 Also Known As   

Porcine Pancreas Specific Transcription Factor 1A ELISA Kit

 Product Gene Name   

PTF1alpha elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 10; NC_000010.10 (23481460..23483181). Location: 10p12.2
 OMIM    607194
 3D Structure    ModBase 3D Structure for Q7RTS3
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 Species Reactivity    Porcine
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PTF1alpha elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PTF1alpha purchase    MBS020218 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Pancreas Specific Transcription Factor 1A (PTF1alpha) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PTF1alpha. The ELISA analytical biochemical technique of the MBS020218 kit is based on PTF1alpha antibody-PTF1alpha antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PTF1alpha antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PTF1alpha. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for PTF1alpha. It may not necessarily be applicable to this product.
 NCBI GI #    30039710
 NCBI GeneID    256297
 NCBI Accession #    NP_835455.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_178161.2 [Other Products]
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 UniProt Primary Accession #    Q7RTS3 [Other Products]
 UniProt Secondary Accession #    Q9HC25 [Other Products]
 UniProt Related Accession #    Q7RTS3 [Other Products]
 Molecular Weight    34,970 Da
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 NCBI Official Full Name    pancreas transcription factor 1 subunit alpha
 NCBI Official Synonym Full Names    pancreas specific transcription factor, 1a
 NCBI Official Symbol    PTF1A [Similar Products]
 NCBI Official Synonym Symbols   
bHLHa29; PTF1-p48
[Similar Products]
 NCBI Protein Information    pancreas transcription factor 1 subunit alpha; class II bHLH protein PTF1A; bHLH transcription factor p48; class A basic helix-loop-helix protein 29; pancreas-specific transcription factor 1a; exocrine pancreas-specific transcription factor p48; p48 DNA-binding subunit of transcription factor PTF1
 UniProt Protein Name    Pancreas transcription factor 1 subunit alpha
 UniProt Synonym Protein Names   
Class A basic helix-loop-helix protein 29; bHLHa29; Pancreas-specific transcription factor 1a; bHLH transcription factor p48; p48 DNA-binding subunit of transcription factor PTF1
 UniProt Gene Name    PTF1A [Similar Products]
 UniProt Synonym Gene Names    BHLHA29; PTF1P48; bHLHa29; PTF1-p48 [Similar Products]
 UniProt Entry Name    PTF1A_HUMAN
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 NCBI Summary for PTF1alpha    This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PTF1alpha    PTF1A: Transcriptional activator. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays an important role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Defects in PTF1A are the cause of diabetes mellitus and cerebellar hypoplasia/agenesis (DMCH).

Chromosomal Location of Human Ortholog: 10p12.2

Cellular Component: transcription factor complex; cytoplasm; nucleus

Molecular Function: protein dimerization activity; DNA binding; sequence-specific DNA binding; chromatin binding

Biological Process: retinoic acid receptor signaling pathway; tissue development; embryonic development; regulation of transcription, DNA-dependent; transcription, DNA-dependent; pancreas development; exocrine pancreas development; neuron fate commitment; cerebellum development; positive regulation of transcription from RNA polymerase II promoter; endocrine pancreas development

Disease: Pancreatic And Cerebellar Agenesis; Pancreatic Agenesis 2
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 Research Articles on PTF1alpha    1. ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PTF1alpha elisa kitPathways associated with PTF1alpha elisa kit
 Reference Product  PubMed Publications
 RBPJ elisa kit  >12 publications with PTF1alpha and RBPJ
 HNF1B elisa kit  >7 publications with PTF1alpha and HNF1B
 HES1 elisa kit  >5 publications with PTF1alpha and HES1
 RBPJL elisa kit  >5 publications with PTF1alpha and RBPJL
 ISL1 elisa kit  >4 publications with PTF1alpha and ISL1
 PAX4 elisa kit  >4 publications with PTF1alpha and PAX4
 FGF10 elisa kit  >4 publications with PTF1alpha and FGF10
 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Notch-mediated HES/HEY Network Pathway antibodies  Notch-mediated HES/HEY Network Pathway Diagram
 Regulation Of Beta-cell Development Pathway antibodies  Regulation Of Beta-cell Development Pathway Diagram
 Regulation Of Gene Expression In Early Pancreatic Precursor Cells Pathway antibodies  Regulation Of Gene Expression In Early Pancreatic Precursor Cells Pathway Diagram
Diseases associated with PTF1alpha elisa kitOrgans/Tissues associated with PTF1alpha elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >10 publications with PTF1alpha and Neoplasms
 Congenital Abnormalities Antibodies  >9 publications with PTF1alpha and Congenital Abnormalities
 Disease Models, Animal Antibodies  >8 publications with PTF1alpha and Disease Models, Animal
 Heart Defects, Congenital Antibodies  >4 publications with PTF1alpha and Heart Defects, Congenital
 Atrophy Antibodies  >2 publications with PTF1alpha and Atrophy
 Inflammation Antibodies  >2 publications with PTF1alpha and Inflammation
 Cell Transformation, Neoplastic Antibodies  >2 publications with PTF1alpha and Cell Transformation, Neoplastic
 Skin Diseases Antibodies  >2 publications with PTF1alpha and Skin Diseases
 Hydrocephalus Antibodies  >1 publications with PTF1alpha and Hydrocephalus
 Learning Disorders Antibodies  >1 publications with PTF1alpha and Learning Disorders
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >99 publications with PTF1alpha and Pancreas
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