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PAPP-A elisa kit :: Porcine Pregnancy Associated Plasma Protein A ELISA Kit

Scan QR to view Datasheet Catalog #    MBS035935 PAPP-A elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Pregnancy Associated Plasma Protein A (PAPP-A), ELISA Kit

 Also Known As   

Porcine Pregnancy Associated Plasma Protein A ELISA Kit

 Product Gene Name   

PAPP-A elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    176385
 3D Structure    ModBase 3D Structure for Q13219
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 Species Reactivity    Porcine
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PAPP-A elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PAPP-A purchase    MBS035935 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Pregnancy Associated Plasma Protein A (PAPP-A) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PAPP-A. The ELISA analytical biochemical technique of the MBS035935 kit is based on PAPP-A antibody-PAPP-A antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PAPP-A antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PAPP-A. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for PAPP-A. It may not necessarily be applicable to this product.
 NCBI GI #    223590248
 NCBI GeneID    5069
 NCBI Accession #    Q13219.3 [Other Products]
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 UniProt Primary Accession #    Q13219 [Other Products]
 UniProt Secondary Accession #    Q08371; Q68G52; Q9UDK7; B1AMF9 [Other Products]
 UniProt Related Accession #    Q13219 [Other Products]
 Molecular Weight    180,973 Da
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 NCBI Official Full Name    Pappalysin-1
 NCBI Official Synonym Full Names    pregnancy-associated plasma protein A, pappalysin 1
 NCBI Official Symbol    PAPPA [Similar Products]
 NCBI Official Synonym Symbols   
PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase
[Similar Products]
 NCBI Protein Information    pappalysin-1; IGF-dependent IGFBP-4 protease; aspecific BCL2 ARE-binding protein 2; pregnacy-associated plasma protein A; differentially placenta 1 expressed protein; insulin-like growth factor-dependent IGF binding protein-4 protease; insulin-like growth factor-dependent IGF-binding protein 4 protease
 UniProt Protein Name    Pappalysin-1
 UniProt Synonym Protein Names   
Insulin-like growth factor-dependent IGF-binding protein 4 protease; IGF-dependent IGFBP-4 protease; IGFBP-4ase; Pregnancy-associated plasma protein A
 UniProt Gene Name    PAPPA [Similar Products]
 UniProt Synonym Gene Names    IGF-dependent IGFBP-4 protease; IGFBP-4ase; PAPP-A [Similar Products]
 UniProt Entry Name    PAPP1_HUMAN
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 NCBI Summary for PAPP-A    This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PAPP-A    PAPPA: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Belongs to the peptidase M43B family.

Protein type: Secreted, signal peptide; Secreted; Protease; EC 3.4.24.79

Chromosomal Location of Human Ortholog: 9q33.2

Cellular Component: membrane; extracellular region

Molecular Function: metallopeptidase activity; zinc ion binding; metalloendopeptidase activity

Biological Process: cellular protein metabolic process; female pregnancy; proteolysis; cell differentiation
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 Research Articles on PAPP-A    1. PAPPA can be used as a novel biomarker for the diagnosis of sepsis-related myocardial dysfunction and the prediction of outcomes in critically ill patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PAPP-A elisa kitPathways associated with PAPP-A elisa kit
 Reference Product  PubMed Publications
 IGFBP4 elisa kit  >8 publications with PAPP-A and IGFBP4
 IGF1 elisa kit  >5 publications with PAPP-A and IGF1
 IGF2 elisa kit  >3 publications with PAPP-A and IGF2
 IGFBP5 elisa kit  >3 publications with PAPP-A and IGFBP5
 PRG2 elisa kit  >1 publications with PAPP-A and PRG2
 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies  Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram
Diseases associated with PAPP-A elisa kitOrgans/Tissues associated with PAPP-A elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >128 publications with PAPP-A and Neoplasms
 Nervous System Diseases Antibodies  >45 publications with PAPP-A and Nervous System Diseases
 Heart Diseases Antibodies  >26 publications with PAPP-A and Heart Diseases
 Inflammation Antibodies  >26 publications with PAPP-A and Inflammation
 Brain Diseases Antibodies  >20 publications with PAPP-A and Brain Diseases
 Lung Diseases Antibodies  >19 publications with PAPP-A and Lung Diseases
 Necrosis Antibodies  >18 publications with PAPP-A and Necrosis
 Uterine Neoplasms Antibodies  >14 publications with PAPP-A and Uterine Neoplasms
 Pain Antibodies  >14 publications with PAPP-A and Pain
 Hypertension Antibodies  >12 publications with PAPP-A and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >63 publications with PAPP-A and Bone
 Bone Marrow Antibodies  >42 publications with PAPP-A and Bone Marrow
 Vascular Antibodies  >39 publications with PAPP-A and Vascular
 Heart Antibodies  >27 publications with PAPP-A and Heart
 Eye Antibodies  >23 publications with PAPP-A and Eye
 Liver Antibodies  >22 publications with PAPP-A and Liver
 Muscle Antibodies  >22 publications with PAPP-A and Muscle
 Lung Antibodies  >17 publications with PAPP-A and Lung
 Brain Antibodies  >17 publications with PAPP-A and Brain
 Skin Antibodies  >14 publications with PAPP-A and Skin
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