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ANKH elisa kit :: Porcine Progressive ankylosis protein homolog ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2604966 ANKH elisa kit
Unit / Price
48-Strip-Wells  /  $315 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,825 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,425 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Progressive ankylosis protein homolog (ANKH), ELISA Kit

 Also Known As   

Porcine Progressive ankylosis protein homolog (ANKH) ELISA Kit

 Product Gene Name   

ANKH elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 OMIM    118600
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 Species Reactivity    Porcine
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of ANKH elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ANKH purchase    MBS2604966 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Progressive ankylosis protein homolog (ANKH) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ANKH. The ELISA analytical biochemical technique of the MBS2604966 kit is based on ANKH antibody-ANKH antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ANKH antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ANKH. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ANKH. It may not necessarily be applicable to this product.
 NCBI GI #    16905507
 NCBI GeneID    56172
 NCBI Accession #    NP_473368.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_054027.4 [Other Products]
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 UniProt Secondary Accession #    Q9NQW2; B2RCA7; B3KMG4; D3DTD4 [Other Products]
 UniProt Related Accession #    Q9HCJ1 [Other Products]
 Molecular Weight    32,259 Da
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 NCBI Official Full Name    progressive ankylosis protein homolog
 NCBI Official Synonym Full Names    ANKH inorganic pyrophosphate transport regulator
 NCBI Official Symbol    ANKH [Similar Products]
 NCBI Official Synonym Symbols   
ANK; CMDJ; HANK; MANK; CCAL2; CPPDD
[Similar Products]
 NCBI Protein Information    progressive ankylosis protein homolog
 UniProt Protein Name    Progressive ankylosis protein homolog
 Protein Family    Progressive ankylosis protein
 UniProt Gene Name    ANKH [Similar Products]
 UniProt Synonym Gene Names    KIAA1581; ANK [Similar Products]
 UniProt Entry Name    ANKH_HUMAN
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 NCBI Summary for ANKH    This gene encodes a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals. Mutations in this gene have been associated with autosomal dominant craniometaphyseal dysplasia. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ANKH    ANKH: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter. Defects in ANKH are the cause of chondrocalcinosis 2 (CCAL2). Chondrocalcinosis is a common cause of joint pain and arthritis caused by calcium deposition in articular cartilage and the presence of calcium hypophosphate crystals in synovial fluid, cartilage and periarticular soft tissue. CCAL2 inheritance is autosomal dominant. Defects in ANKH are the cause of craniometaphyseal dysplasia Jackson type (CMDJ). CMDJ is a rare autosomal dominant skeletal disorder characterized by abnormal bone formation and mineralization in membranous as well as endochondral bones. Progressive thickening of the bones can cause narrowing of cranial foramina and can lead to severe visual and neurological impairment, such as facial palsy and deafness. Belongs to the ANKH family.

Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5p15.1

Cellular Component: integral to membrane; integral to plasma membrane; outer membrane; plasma membrane

Molecular Function: inorganic diphosphate transmembrane transporter activity; inorganic phosphate transmembrane transporter activity; phosphate transmembrane transporter activity

Biological Process: inorganic diphosphate transport; locomotory behavior; regulation of bone mineralization; skeletal development; transmembrane transport

Disease: Chondrocalcinosis 2; Craniometaphyseal Dysplasia, Autosomal Dominant
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 Research Articles on ANKH    1. This study validates the association between a functional polymorphism in the 5' UTR of ANKH and Chondrocalcinosis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ANKH elisa kitPathways associated with ANKH elisa kit
 Reference Product  PubMed Publications
 ENPP1 elisa kit  >17 publications with ANKH and ENPP1
 LRCH1 elisa kit  >1 publications with ANKH and LRCH1
 ESR1 elisa kit  >1 publications with ANKH and ESR1
 Products by Pathway  Pathway Diagram
 Miscellaneous Transport And Binding Events Pathway antibodies  Miscellaneous Transport And Binding Events Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
Diseases associated with ANKH elisa kitOrgans/Tissues associated with ANKH elisa kit
 Disease Name  Pubmed Publications
 Craniofacial Abnormalities Antibodies  >14 publications with ANKH and Craniofacial Abnormalities
 Nervous System Diseases Antibodies  >12 publications with ANKH and Nervous System Diseases
 Disease Models, Animal Antibodies  >12 publications with ANKH and Disease Models, Animal
 Inflammation Antibodies  >6 publications with ANKH and Inflammation
 Kidney Diseases Antibodies  >6 publications with ANKH and Kidney Diseases
 Tooth Abnormalities Antibodies  >4 publications with ANKH and Tooth Abnormalities
 Abnormalities, Multiple Antibodies  >3 publications with ANKH and Abnormalities, Multiple
 Craniometaphyseal Dysplasia, Autosomal Dominant Antibodies  >3 publications with ANKH and Craniometaphyseal Dysplasia, Autosomal Dominant
 Necrosis Antibodies  >2 publications with ANKH and Necrosis
 Liver Diseases Antibodies  >2 publications with ANKH and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >59 publications with ANKH and Bone
 Connective Tissue Antibodies  >14 publications with ANKH and Connective Tissue
 Blood Antibodies  >9 publications with ANKH and Blood
 Kidney Antibodies  >7 publications with ANKH and Kidney
 Parathyroid Antibodies  >6 publications with ANKH and Parathyroid
 Muscle Antibodies  >5 publications with ANKH and Muscle
 Nerve Antibodies  >5 publications with ANKH and Nerve
 Brain Antibodies  >5 publications with ANKH and Brain
 Mouth Antibodies  >2 publications with ANKH and Mouth
 Embryonic Tissue Antibodies  >2 publications with ANKH and Embryonic Tissue
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