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POMC elisa kit :: Porcine Proopiomelanocortin ELISA Kit

Scan QR to view Datasheet Catalog #    MBS016119 POMC elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Proopiomelanocortin (POMC), ELISA Kit

 Also Known As   

Porcine Proopiomelanocortin ELISA Kit

 Product Gene Name   

POMC elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 2; NC_000002.11 (25383722..25391559, complement). Location: 2p23.3
 3D Structure    ModBase 3D Structure for Q6FHC8
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 Species Reactivity    Porcine
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of POMC elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for POMC purchase    MBS016119 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Proopiomelanocortin (POMC) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing POMC. The ELISA analytical biochemical technique of the MBS016119 kit is based on POMC antibody-POMC antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect POMC antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, POMC. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for POMC. It may not necessarily be applicable to this product.
 NCBI GI #    49456609
 NCBI GeneID    5443
 NCBI Accession #    CAG46625.1 [Other Products]
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 UniProt Primary Accession #    Q6FHC8 [Other Products]
 UniProt Related Accession #    P01189 [Other Products]
 Molecular Weight    29,410 Da
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 NCBI Official Full Name    POMC
 NCBI Official Synonym Full Names    proopiomelanocortin
 NCBI Official Symbol    POMC [Similar Products]
 NCBI Official Synonym Symbols   
LPH; MSH; NPP; POC; ACTH; CLIP
[Similar Products]
 NCBI Protein Information    pro-opiomelanocortin; beta-LPH; beta-MSH; alpha-MSH; gamma-LPH; gamma-MSH; beta-endorphin; met-enkephalin; lipotropin beta; lipotropin gamma; melanotropin beta; melanotropin alpha; melanotropin gamma; pro-ACTH-endorphin; adrenocorticotropin; corticotropin-lipotropin; adrenocorticotropic hormone; opiomelanocortin prepropeptide; proopiomelanocortin preproprotein; beta-melanocyte-stimulating hormone; alpha-melanocyte-stimulating hormone; corticotropin-like intermediary peptide
 UniProt Protein Name    POMC protein
 Protein Family    Pro-opiomelanocortin
 UniProt Gene Name    POMC [Similar Products]
 UniProt Entry Name    Q6FHC8_HUMAN
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 NCBI Summary for POMC    This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for POMC    POMC: ACTH stimulates the adrenal glands to release cortisol. Defects in POMC may be associated with susceptibility to obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD). Affected individuals present early-onset obesity, adrenal insufficiency and red hair. Belongs to the POMC family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: extracellular space; peroxisomal matrix; cytoplasm; extracellular region; peroxisome; secretory granule

Molecular Function: type 3 melanocortin receptor binding; G-protein-coupled receptor binding; hormone activity; type 4 melanocortin receptor binding; receptor binding

Biological Process: generation of precursor metabolites and energy; cellular protein metabolic process; cell-cell signaling; neuropeptide signaling pathway; regulation of blood pressure; peptide hormone processing; regulation of appetite; positive regulation of transcription from RNA polymerase II promoter; negative regulation of tumor necrosis factor production; signal transduction; glucose homeostasis; cellular pigmentation

Disease: Obesity; Proopiomelanocortin Deficiency
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 Research Articles on POMC    1. The investigation of single nucleotide polymorphisms in three genes that have a functional impact on the opioid response: OPRM1, ABCB1 and the calcium channel complex subunit CACNA2D2, is reported.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with POMC elisa kitDiseases associated with POMC elisa kit
 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Endogenous Sterols Pathway antibodies  Endogenous Sterols Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 G-protein Activation Pathway antibodies  G-protein Activation Pathway Diagram
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >4160 publications with POMC and Immune System Diseases
 Cushing Syndrome Antibodies  >2835 publications with POMC and Cushing Syndrome
 Mental Disorders Antibodies  >2587 publications with POMC and Mental Disorders
 Obesity Antibodies  >1576 publications with POMC and Obesity
 Kidney Diseases Antibodies  >988 publications with POMC and Kidney Diseases
 Infection Antibodies  >986 publications with POMC and Infection
 Gastrointestinal Diseases Antibodies  >934 publications with POMC and Gastrointestinal Diseases
 Diabetes Mellitus Antibodies  >826 publications with POMC and Diabetes Mellitus
 Hemorrhage Antibodies  >663 publications with POMC and Hemorrhage
 Necrosis Antibodies  >649 publications with POMC and Necrosis
Organs/Tissues associated with POMC elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17909 publications with POMC and Brain
 Pituitary Gland Antibodies  >8904 publications with POMC and Pituitary Gland
 Lung Antibodies  >969 publications with POMC and Lung
 Eye Antibodies  >590 publications with POMC and Eye
 Testis Antibodies  >546 publications with POMC and Testis
 Intestine Antibodies  >416 publications with POMC and Intestine
 Embryonic Tissue Antibodies  >381 publications with POMC and Embryonic Tissue
 Placenta Antibodies  >362 publications with POMC and Placenta
 Uterus Antibodies  >237 publications with POMC and Uterus
 Uncharacterized Tissue Antibodies  >2 publications with POMC and Uncharacterized Tissue
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