NP_115582.4
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
170,417 Da
NCBI Official Full Name
protein NLRC5
NCBI Official Synonym Full Names
NLR family, CARD domain containing 5
NCBI Protein Information
protein NLRC5
UniProt Protein Name
Protein NLRC5
UniProt Synonym Protein Names
Caterpiller protein 16.1; CLR16.1; Nucleotide-binding oligomerization domain protein 27; Nucleotide-binding oligomerization domain protein 4
UniProt Synonym Gene Names
UniProt Entry Name
NLRC5_HUMAN
NCBI Summary for NLRC5
This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]
UniProt Comments for NLRC5
NLRC5: Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. Belongs to the NLRP family. 6 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 16q13
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: ATP binding; protein binding
Biological Process: defense response to virus; inhibition of NF-kappaB transcription factor; innate immune response; negative regulation of interferon type I production; positive regulation of MHC class I biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; regulation of kinase activity
Research Articles on NLRC5
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Products associated with NLRC5 elisa kit
Pathways associated with NLRC5 elisa kit
Diseases associated with NLRC5 elisa kit
Organs/Tissues associated with NLRC5 elisa kit
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