NP_002756.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,054 Da
NCBI Official Full Name
ribose-phosphate pyrophosphokinase 2 isoform 2
NCBI Official Synonym Full Names
phosphoribosyl pyrophosphate synthetase 2
NCBI Official Synonym Symbols
NCBI Protein Information
ribose-phosphate pyrophosphokinase 2; PRS-II; PPRibP synthetase; ribose-phosphate diphosphokinase 2; phosphoribosyl pyrophosphate synthase II
UniProt Protein Name
Ribose-phosphate pyrophosphokinase 2
UniProt Synonym Protein Names
PPRibP; Phosphoribosyl pyrophosphate synthase II; PRS-II
UniProt Synonym Gene Names
UniProt Entry Name
PRPS2_HUMAN
NCBI Summary for PRPS2
This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
UniProt Comments for PRPS2
PRPS2: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Belongs to the ribose-phosphate pyrophosphokinase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Kinase, other; Carbohydrate Metabolism - pentose phosphate pathway; Nucleotide Metabolism - purine; EC 2.7.6.1
Chromosomal Location of Human Ortholog: Xp22.2
Molecular Function: ribose phosphate diphosphokinase activity; protein homodimerization activity; GDP binding; magnesium ion binding; kinase activity; ADP binding; carbohydrate binding; ATP binding; AMP binding
Biological Process: AMP biosynthetic process; organ regeneration; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; 5-phosphoribose 1-diphosphate biosynthetic process; phosphorylation
Research Articles on PRPS2
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Pathways associated with PRPS2 elisa kit
Diseases associated with PRPS2 elisa kit
Organs/Tissues associated with PRPS2 elisa kit
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