NP_001020018.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
67,457 Da
NCBI Official Full Name
TGF-beta receptor type-2 isoform A
NCBI Official Synonym Full Names
transforming growth factor, beta receptor II (70/80kDa)
NCBI Official Synonym Symbols
AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII [Similar Products]
NCBI Protein Information
TGF-beta receptor type-2; tbetaR-II; TGF-beta type II receptor; TGF-beta receptor type IIB; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II alpha; transforming growth factor, beta receptor II delta; transforming growth factor, beta receptor II gamma; transforming growth factor, beta receptor II epsilon
UniProt Protein Name
TGF-beta receptor type-2
UniProt Synonym Protein Names
TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II
UniProt Synonym Gene Names
UniProt Entry Name
TGFR2_HUMAN
NCBI Summary for TGFBR2
This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for TGFBR2
TGFBR2: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Binds to DAXX. Defects can cause esophageal cancer.
Protein type: Oncoprotein; Membrane protein, integral; EC 2.7.11.30; Protein kinase, TKL; Kinase, protein; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type2 subfamily
Chromosomal Location of Human Ortholog: 3p22
Cellular Component: integral to membrane; plasma membrane; caveola; cytosol; receptor complex; external side of plasma membrane
Molecular Function: transforming growth factor beta receptor activity; protein binding; glycosaminoglycan binding; transforming growth factor beta receptor activity, type II; transforming growth factor beta binding; metal ion binding; mitogen-activated protein kinase kinase kinase binding; SMAD binding; transmembrane receptor protein serine/threonine kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity
Biological Process: lens development in camera-type eye; wound healing; apoptosis; heart development; positive regulation of smooth muscle cell proliferation; myeloid dendritic cell differentiation; gastrulation; palate development; positive regulation of tolerance induction to self antigen; protein amino acid phosphorylation; negative regulation of cardiac muscle cell proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; response to glucose stimulus; positive regulation of NK T cell differentiation; vasculogenesis; response to nutrient; positive regulation of T cell tolerance induction; aging; response to drug; blood vessel development; receptor-mediated endocytosis; smoothened signaling pathway; organ regeneration; positive regulation of skeletal muscle regeneration; in utero embryonic development; embryonic hemopoiesis; common-partner SMAD protein phosphorylation; peptidyl-threonine phosphorylation; embryonic cranial skeleton morphogenesis; regulation of cell proliferation; patterning of blood vessels; positive regulation of angiogenesis; peptidyl-serine phosphorylation; gut development; response to estrogen stimulus; response to mechanical stimulus; regulation of gene expression; positive regulation of B cell tolerance induction; activation of protein kinase activity; brain development; negative regulation of transforming growth factor beta receptor signaling pathway; embryo implantation
Disease: Colorectal Cancer, Hereditary Nonpolyposis, Type 6; Loeys-dietz Syndrome 2; Esophageal Cancer
Research Articles on TGFBR2
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Pathways associated with TGFBR2 elisa kit
Diseases associated with TGFBR2 elisa kit
Organs/Tissues associated with TGFBR2 elisa kit
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