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TJP1 elisa kit :: Porcine Tight Junction Protein 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS016326 TJP1 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tight Junction Protein 1 (TJP1), ELISA Kit

 Also Known As   

Porcine Tight Junction Protein 1 ELISA Kit

 Product Gene Name   

TJP1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    607709
 3D Structure    ModBase 3D Structure for Q9UDY2
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 Species Reactivity    Porcine
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TJP1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TJP1 purchase    MBS016326 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Tight Junction Protein 1 (TJP1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TJP1. The ELISA analytical biochemical technique of the MBS016326 kit is based on TJP1 antibody-TJP1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TJP1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TJP1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for TJP1. It may not necessarily be applicable to this product.
 NCBI GI #    42518070
 NCBI GeneID    9414
 NCBI Accession #    NP_004808.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004817.3 [Other Products]
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 UniProt Primary Accession #    Q9UDY2 [Other Products]
 UniProt Secondary Accession #    Q15883; Q5VXL0; Q5VXL1; Q8N756; Q8NI14; Q99839; A2A3H9; B7Z2R8; B7Z7T6; F5H301; F5H886 [Other Products]
 UniProt Related Accession #    Q9UDY2 [Other Products]
 Molecular Weight    133,958 Da
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 NCBI Official Full Name    tight junction protein ZO-2 isoform 1
 NCBI Official Synonym Full Names    tight junction protein 2
 NCBI Official Symbol    TJP2 [Similar Products]
 NCBI Official Synonym Symbols   
ZO2; X104; PFIC4; DFNA51; DUP9q21.11; C9DUPq21.11
[Similar Products]
 NCBI Protein Information    tight junction protein ZO-2; zona occludens 2; zonula occludens protein 2; Friedreich ataxia region gene X104 (tight junction protein ZO-2)
 UniProt Protein Name    Tight junction protein ZO-2
 UniProt Synonym Protein Names   
Tight junction protein 2; Zona occludens protein 2; Zonula occludens protein 2
 Protein Family    Tight junction protein
 UniProt Gene Name    TJP2 [Similar Products]
 UniProt Synonym Gene Names    X104; ZO2 [Similar Products]
 UniProt Entry Name    ZO2_HUMAN
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 NCBI Summary for TJP1    This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
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 UniProt Comments for TJP1    ZO2: a scaffolding protein of the MAGUK (membrane-associated guanylate kinase) family associated with epithelial tight junctions (TJ). May mediate dynamic changes in the composition of TJs. Plays a role in tight junctions and adherens junctions. Forms homodimers, and heterodimer with ZO-1 and ZO-3. The ZOs shuttle between the TJ and the nucleus, where they may regulate gene expression. Interacts with occluding, UBN1 and scribble. Interacts with SAFB in the nucleus. TJ, or zonula occludens, are the closely associated areas of two cells whose membranes are tightly joined together. They are composed of a branching network of strands, the efficiency of which increases exponentially with the number of strands. The strands associate with transmembrane proteins that bind to similar proteins on adjacent cells, and with submembranous proteins that are anchored to the actin component of the cytoskeleton. Thus, TJs join together the cytoskeletons of adjacent cells. They endow tissues with substantial form, shape and location, enforce cellular polarity, and form barriers to molecules and pathogens. Molecules forming the membranous part of TJs include occludin, claudins, tricellulin and junctional adhesion molecules. These molecules interact with the proteins ZO-1, ZO-2 and ZO-3. Tight junction proteins are involved in the epithelial-mesenchymal transitions (EMT) in tumors. Five isoforms of the human protein are produced by alternative promoters. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues..

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q13-q21

Cellular Component: nucleoplasm; adherens junction; tight junction; cytoplasm; plasma membrane; cell junction; cytosol

Molecular Function: protein binding, bridging; protein C-terminus binding; guanylate kinase activity; protein domain specific binding; protein binding

Biological Process: response to organic substance; apoptosis; intestinal absorption; nucleotide phosphorylation; cell structure disassembly during apoptosis

Disease: Hypercholanemia, Familial; Cholestasis, Progressive Familial Intrahepatic, 4
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 Research Articles on TJP1    1. Protein-truncating mutations in the tight junction protein 2 gene cause failure of protein localization and disruption of tight-junction structure, leading to severe cholestatic liver disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TJP1 elisa kitPathways associated with TJP1 elisa kit
 Reference Product  PubMed Publications
 TJP1 elisa kit  >87 publications with TJP1 and TJP1
 OCLN elisa kit  >48 publications with TJP1 and OCLN
 CLDN1 elisa kit  >21 publications with TJP1 and CLDN1
 CLDN2 elisa kit  >6 publications with TJP1 and CLDN2
 CGN elisa kit  >2 publications with TJP1 and CGN
 GJA1 elisa kit  >1 publications with TJP1 and GJA1
 WWTR1 elisa kit  >1 publications with TJP1 and WWTR1
 SAFB elisa kit  >1 publications with TJP1 and SAFB
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cell Adhesion Proteins Pathway antibodies  Apoptotic Cleavage Of Cell Adhesion Proteins Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Hippo Pathway antibodies  Signaling By Hippo Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Repression Pathway antibodies  Validated Targets Of C-MYC Transcriptional Repression Pathway Diagram
 Vibrio Cholerae Infection Pathway antibodies  Vibrio Cholerae Infection Pathway Diagram
Diseases associated with TJP1 elisa kitOrgans/Tissues associated with TJP1 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >14 publications with TJP1 and Neoplasms
 Nervous System Diseases Antibodies  >10 publications with TJP1 and Nervous System Diseases
 Inflammation Antibodies  >8 publications with TJP1 and Inflammation
 Brain Diseases Antibodies  >7 publications with TJP1 and Brain Diseases
 Liver Diseases Antibodies  >5 publications with TJP1 and Liver Diseases
 Necrosis Antibodies  >5 publications with TJP1 and Necrosis
 Edema Antibodies  >4 publications with TJP1 and Edema
 Disease Models, Animal Antibodies  >4 publications with TJP1 and Disease Models, Animal
 Hearing Loss Antibodies  >4 publications with TJP1 and Hearing Loss
 Breast Neoplasms Antibodies  >3 publications with TJP1 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >14 publications with TJP1 and Intestine
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