AAA61140.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
77,064 Da
NCBI Official Full Name
transferrin
NCBI Official Synonym Full Names
transferrin
NCBI Protein Information
serotransferrin; siderophilin; beta-1 metal-binding globulin
UniProt Protein Name
Serotransferrin
UniProt Synonym Protein Names
Beta-1 metal-binding globulin; Siderophilin
UniProt Synonym Gene Names
UniProt Entry Name
TRFE_HUMAN
NCBI Summary for TRF
This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]
UniProt Comments for TRF
TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3q22.1
Cellular Component: extracellular space; cell surface; cytoplasmic membrane-bound vesicle; early endosome; extracellular region; coated pit; recycling endosome; perinuclear region of cytoplasm; endocytic vesicle; apical plasma membrane; late endosome; basal plasma membrane; endosome membrane; vesicle
Molecular Function: protein binding; ferric iron binding; ubiquitin protein ligase binding
Biological Process: retinal homeostasis; platelet activation; platelet degranulation; cellular iron ion homeostasis; transferrin transport; blood coagulation; transmembrane transport
Disease: Atransferrinemia
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Products associated with TRF elisa kit
Pathways associated with TRF elisa kit
Diseases associated with TRF elisa kit
Organs/Tissues associated with TRF elisa kit
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