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PTPN11 elisa kit :: Porcine Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7243588 PTPN11 elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11), ELISA Kit

 Also Known As   

Porcine Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) ELISA Kit

 Product Gene Name   

PTPN11 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Species Reactivity    Porcine
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PTPN11 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PTPN11 purchase    MBS7243588 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PTPN11. The ELISA analytical biochemical technique of the MBS7243588 kit is based on PTPN11 antibody-PTPN11 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PTPN11 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PTPN11. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for PTPN11 elisa kit    Signal Transduction
NCBI/Uniprot data below describe general gene information for PTPN11. It may not necessarily be applicable to this product.
 NCBI GI #    294862239
 NCBI GeneID    25622
 NCBI Accession #    NP_001171064.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001177593.1 [Other Products]
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 UniProt Secondary Accession #    Q62626 [Other Products]
 UniProt Related Accession #    P41499 [Other Products]
 Molecular Weight    68,033 Da
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 NCBI Official Full Name    tyrosine-protein phosphatase non-receptor type 11 isoform 1
 NCBI Official Synonym Full Names    protein tyrosine phosphatase, non-receptor type 11
 NCBI Official Symbol    Ptpn11 [Similar Products]
 NCBI Official Synonym Symbols   
Shp2
[Similar Products]
 NCBI Protein Information    tyrosine-protein phosphatase non-receptor type 11; null; SHP-2; PTP-1D; encodes catalytic domain; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase SYP; protein tyrosine phosphatase SH-PTP2; SH-PTP2 protein tyrosine phosphatase non-receptor type 11; SH-PTP2 protein tyrosine phosphatase, non-receptor type 11
 UniProt Protein Name    Tyrosine-protein phosphatase non-receptor type 11
 UniProt Synonym Protein Names   
Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase SYP; SH-PTP2; SHP-2; Shp2
 Protein Family    Tyrosine-protein phosphatase non-receptor
 UniProt Gene Name    Ptpn11 [Similar Products]
 UniProt Synonym Gene Names    PTP-1D; SHP-2; Shp2 [Similar Products]
 UniProt Entry Name    PTN11_RAT
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 NCBI Summary for PTPN11    catalyzes the tyrosine dephosphorylation of para-nitrophenylphosphate, nicotinic acetylcholine receptor, myelin basic protein, and other proteins [RGD, Feb 2006]
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 UniProt Comments for PTPN11    SHP-2: a SH2-containing a ubiquitously expressed tyrosine-specific protein phosphatase. It participates in signaling events downstream of receptors for growth factors, cytokines, hormones, antigens and extracellular matrices in the control of cell growth, differentiation, migration, and death. Activation of SHP-2 and its association with Gab1 is critical for sustained Erk activation downstream of several growth factor receptors and cytokines.

Protein type: EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis

Cellular Component: protein complex; mitochondrion; cytoplasm; nucleus; cytosol

Molecular Function: protein domain specific binding; protein binding; phospholipase binding; SH3/SH2 adaptor activity; peptide hormone receptor binding; insulin receptor substrate binding; non-membrane spanning protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; D1 dopamine receptor binding; phosphoprotein phosphatase activity; insulin receptor binding

Biological Process: hormone-mediated signaling; nerve growth factor receptor signaling pathway; activation of MAPK activity; negative regulation of hormone secretion; heart development; platelet-derived growth factor receptor signaling pathway; protein amino acid dephosphorylation; positive regulation of mitotic cell cycle; glucose homeostasis; reproductive process in a multicellular organism; regulation of protein export from nucleus; negative regulation of insulin secretion; regulation of cell adhesion mediated by integrin; microvillus organization and biogenesis; ephrin receptor signaling pathway; abortive mitotic cell cycle; inner ear development; negative regulation of cell adhesion mediated by integrin; epidermal growth factor receptor signaling pathway; integrin-mediated signaling pathway; negative regulation of growth hormone secretion; positive regulation of signal transduction; multicellular organism growth; positive regulation of hormone secretion; regulation of multicellular organism growth; negative regulation of cortisol secretion; organ growth; genitalia development; triacylglycerol metabolic process; axonogenesis; dephosphorylation; homeostasis of number of cells within a tissue; DNA damage checkpoint; hormone metabolic process; brain development; platelet formation; lipid metabolic process
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 Research Articles on PTPN11    1. Data indicate that protein tyrosine phosphatases SHP-1, SHP-2 and PTP1B overexpressed during the development of cerulein -induced acute pancreatitis can be modulated by extracellular signal-regulated kinases (ERK1/2) and c-Jun NH2-terminal kinase (JNK).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PTPN11 elisa kitPathways associated with PTPN11 elisa kit
 Reference Product  PubMed Publications
 Src elisa kit  >742 publications with PTPN11 and Src
 Grb2 elisa kit  >170 publications with PTPN11 and Grb2
 Jak2 elisa kit  >98 publications with PTPN11 and Jak2
 Stat1 elisa kit  >53 publications with PTPN11 and Stat1
 Gab2 elisa kit  >50 publications with PTPN11 and Gab2
 Egfr elisa kit  >45 publications with PTPN11 and Egfr
 Jak1 elisa kit  >37 publications with PTPN11 and Jak1
 Ptk2 elisa kit  >26 publications with PTPN11 and Ptk2
 Sirpa elisa kit  >13 publications with PTPN11 and Sirpa
 Frs3 elisa kit  >4 publications with PTPN11 and Frs3
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 CTLA4 Inhibitory Signaling Pathway antibodies  CTLA4 Inhibitory Signaling Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
Diseases associated with PTPN11 elisa kitOrgans/Tissues associated with PTPN11 elisa kit
 Disease Name  Pubmed Publications
 Noonan Syndrome Antibodies  >364 publications with PTPN11 and Noonan Syndrome
 Heart Diseases Antibodies  >354 publications with PTPN11 and Heart Diseases
 Congenital Abnormalities Antibodies  >350 publications with PTPN11 and Congenital Abnormalities
 Leukemia Antibodies  >268 publications with PTPN11 and Leukemia
 LEOPARD Syndrome Antibodies  >125 publications with PTPN11 and LEOPARD Syndrome
 Leukemia, Myelomonocytic, Juvenile Antibodies  >89 publications with PTPN11 and Leukemia, Myelomonocytic, Juvenile
 Carcinoma Antibodies  >79 publications with PTPN11 and Carcinoma
 Inflammation Antibodies  >62 publications with PTPN11 and Inflammation
 Costello Syndrome Antibodies  >44 publications with PTPN11 and Costello Syndrome
 Adenocarcinoma Antibodies  >40 publications with PTPN11 and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >183 publications with PTPN11 and Heart
 Muscle Antibodies  >114 publications with PTPN11 and Muscle
 Brain Antibodies  >97 publications with PTPN11 and Brain
 Kidney Antibodies  >42 publications with PTPN11 and Kidney
 Lung Antibodies  >41 publications with PTPN11 and Lung
 Embryonic Tissue Antibodies  >36 publications with PTPN11 and Embryonic Tissue
 Spleen Antibodies  >33 publications with PTPN11 and Spleen
 Eye Antibodies  >27 publications with PTPN11 and Eye
 Ovary Antibodies  >24 publications with PTPN11 and Ovary
 Connective Tissue Antibodies  >11 publications with PTPN11 and Connective Tissue
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