NP_009053.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,372 Da
NCBI Official Full Name
upstream stimulatory factor 1 isoform 1
NCBI Official Synonym Full Names
upstream transcription factor 1
NCBI Official Synonym Symbols
UEF; FCHL; MLTF; FCHL1; MLTFI; HYPLIP1; bHLHb11 [Similar Products]
NCBI Protein Information
upstream stimulatory factor 1
UniProt Protein Name
Upstream stimulatory factor 1
UniProt Synonym Protein Names
Class B basic helix-loop-helix protein 11; bHLHb11; Major late transcription factor 1
UniProt Synonym Gene Names
UniProt Entry Name
USF1_HUMAN
NCBI Summary for USF1
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013]
UniProt Comments for USF1
USF1: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an homodimer or a heterodimer (USF1/USF2). Interacts with varicella-zoster virus IE62 protein.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 1q22-q23
Cellular Component: nucleoplasm; nucleus; transcription factor complex
Molecular Function: bHLH transcription factor binding; double-stranded DNA binding; enzyme binding; histone deacetylase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding
Biological Process: cellular response to insulin stimulus; glucose homeostasis; glucose metabolic process; late viral mRNA transcription; lipid homeostasis; negative regulation of fibrinolysis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter by glucose; regulation of transcription by carbon catabolites; regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter by glucose; response to hypoxia; response to UV; transcription from RNA polymerase II promoter
Disease: Hyperlipidemia, Combined, 1
Research Articles on USF1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with USF1 elisa kit
Pathways associated with USF1 elisa kit
Diseases associated with USF1 elisa kit
Organs/Tissues associated with USF1 elisa kit
|