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WNT4 elisa kit :: Porcine Wingless-Type Mmtv Integration Site Family, Member 4 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS030102 WNT4 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Wingless-Type Mmtv Integration Site Family, Member 4 (WNT4), ELISA Kit

 Also Known As   

Porcine Wingless-Type Mmtv Integration Site Family, Member 4 ELISA Kit

 Product Gene Name   

WNT4 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 1; NC_000001.10 (22443798..22469519, complement). Location: 1p36.23-p35.1
 OMIM    158330
 3D Structure    ModBase 3D Structure for P56705
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 Species Reactivity    Porcine
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of WNT4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for WNT4 purchase    MBS030102 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Wingless-Type Mmtv Integration Site Family, Member 4 (WNT4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing WNT4. The ELISA analytical biochemical technique of the MBS030102 kit is based on WNT4 antibody-WNT4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect WNT4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, WNT4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for WNT4. It may not necessarily be applicable to this product.
 NCBI GI #    13430197
 NCBI GeneID    54361
 NCBI Accession #    AAK25765.1 [Other Products]
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 UniProt Primary Accession #    P56705 [Other Products]
 UniProt Secondary Accession #    Q5TZQ0; Q96T81; Q9BXF5; Q9H1J8; Q9UJM2 [Other Products]
 UniProt Related Accession #    P56705 [Other Products]
 Molecular Weight    39,052 Da
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 NCBI Official Full Name    WNT4
 NCBI Official Synonym Full Names    wingless-type MMTV integration site family, member 4
 NCBI Official Symbol    WNT4 [Similar Products]
 NCBI Official Synonym Symbols   
WNT-4; SERKAL
[Similar Products]
 NCBI Protein Information    protein Wnt-4
 UniProt Protein Name    Protein Wnt-4
 UniProt Gene Name    WNT4 [Similar Products]
 UniProt Entry Name    WNT4_HUMAN
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 NCBI Summary for WNT4    The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008]
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 UniProt Comments for WNT4    WNT4: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Overexpression may be associated with abnormal proliferation in human breast tissue. Defects in WNT4 are a cause of Rokitansky-Kuster-Hauser syndrome (RKH syndrome); also called Mayer- Rokitansky-Kuster-Hauser syndrome (MRKH syndrome or MRKH anomaly). RKH syndrome is characterized by utero-vaginal atresia in otherwise phenotypically normal female with a normal 46,XX karyotype. Anomalies of the genital tract range from upper vaginal atresia to total Muellerian agenesis with urinary tract abnormalities. It has an incidence of approximately 1 in 5'000 newborn girls. Defects in WNT4 are the cause of female sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL); also known as SERKAL syndrome. Defects in WNT4 are the cause of Muellerian aplasia (MULLAPL). Belongs to the Wnt family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.23-p35.1

Cellular Component: proteinaceous extracellular matrix; extracellular space; cell surface; Golgi lumen; endoplasmic reticulum lumen; cytoplasm; plasma membrane; extracellular region

Molecular Function: frizzled binding; transcription corepressor activity; receptor agonist activity

Biological Process: negative regulation of fibroblast growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; thyroid stimulating hormone secreting cell differentiation; androgen biosynthetic process; Wnt receptor signaling pathway through beta-catenin; somatotropin secreting cell differentiation; neuron differentiation; regulation of cell-cell adhesion; positive regulation of focal adhesion formation; positive regulation of aldosterone biosynthetic process; positive regulation of stress fiber formation; embryonic epithelial tube formation; kidney development; negative regulation of cell migration; female gonad development; cell fate commitment; positive regulation of meiosis; adrenal gland development; male gonad development; immature T cell proliferation in the thymus; positive regulation of bone mineralization; liver development; cellular response to starvation; positive regulation of osteoblast differentiation; negative regulation of cell differentiation; protein palmitoylation; ureteric bud branching; epithelial to mesenchymal transition; female sex determination; smooth muscle cell differentiation; negative regulation of transcription, DNA-dependent; oocyte development

Disease: Mullerian Aplasia And Hyperandrogenism; 46,xx Sex Reversal With Dysgenesis Of Kidneys, Adrenals, And Lungs
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 Research Articles on WNT4    1. heterozygous WNT4 variants are likely to play a causative role in renal hypodysplasia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with WNT4 elisa kitPathways associated with WNT4 elisa kit
 Reference Product  PubMed Publications
 PAX2 elisa kit  >23 publications with WNT4 and PAX2
 SFRP1 elisa kit  >12 publications with WNT4 and SFRP1
 SFRP2 elisa kit  >12 publications with WNT4 and SFRP2
 FZD6 elisa kit  >7 publications with WNT4 and FZD6
 SFRP4 elisa kit  >6 publications with WNT4 and SFRP4
 FZD4 elisa kit  >6 publications with WNT4 and FZD4
 FZD10 elisa kit  >5 publications with WNT4 and FZD10
 FZD9 elisa kit  >3 publications with WNT4 and FZD9
 FZD8 elisa kit  >1 publications with WNT4 and FZD8
 Products by Pathway  Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
Diseases associated with WNT4 elisa kitOrgans/Tissues associated with WNT4 elisa kit
 Disease Name  Pubmed Publications
 Female Urogenital Diseases Antibodies  >69 publications with WNT4 and Female Urogenital Diseases
 Urogenital Abnormalities Antibodies  >36 publications with WNT4 and Urogenital Abnormalities
 Disorders of Sex Development Antibodies  >33 publications with WNT4 and Disorders of Sex Development
 Disease Models, Animal Antibodies  >16 publications with WNT4 and Disease Models, Animal
 Kidney Diseases Antibodies  >16 publications with WNT4 and Kidney Diseases
 Rokitansky Kuster Hauser syndrome Antibodies  >11 publications with WNT4 and Rokitansky Kuster Hauser syndrome
 Fibrosis Antibodies  >11 publications with WNT4 and Fibrosis
 Infertility, Female Antibodies  >8 publications with WNT4 and Infertility, Female
 Breast Neoplasms Antibodies  >8 publications with WNT4 and Breast Neoplasms
 Liver Diseases Antibodies  >7 publications with WNT4 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >94 publications with WNT4 and Kidney
 Embryonic Tissue Antibodies  >75 publications with WNT4 and Embryonic Tissue
 Ovary Antibodies  >74 publications with WNT4 and Ovary
 Uterus Antibodies  >39 publications with WNT4 and Uterus
 Brain Antibodies  >27 publications with WNT4 and Brain
 Mammary Gland Antibodies  >23 publications with WNT4 and Mammary Gland
 Eye Antibodies  >17 publications with WNT4 and Eye
 Heart Antibodies  >8 publications with WNT4 and Heart
 Lung Antibodies  >7 publications with WNT4 and Lung
 Placenta Antibodies  >5 publications with WNT4 and Placenta
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