NP_001261288.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
278,303 Da
NCBI Official Full Name
alpha spectrin, isoform D
NCBI Official Synonym Full Names
alpha Spectrin
NCBI Official Synonym Symbols
3A9; alfa-Spec; alpha; alpha-Sp; alpha-Spc; alpha-Spe; alpha-spec; alpha-SPEC; alpha-Spect; alpha-spectrin; alpha-Spectrin; alphaSp; alphaSpec; alphaSpectrin; anon-EST:fe2E2; CG1977; DmelCG1977; dre3; FBtr0072789; FCP-B; klo; l(3)04276; l(3)62Bd; l(3)alph [Similar Products]
NCBI Protein Information
CG1977 gene product from transcript CG1977-RA; CG1977-PA; CG1977-PB; CG1977-PC; CG1977-PD; aSpc 3A9; alpha spectrin; alpha-SPECTRIN; alpha-Spec-PA; alpha-Spec-PB; alpha-Spec-PC; alpha-Spec-PD; alpha-spectrin II; alphaSpectrin; anon-fast-evolving-2E2; klotzchen
UniProt Protein Name
Spectrin alpha chain
UniProt Synonym Gene Names
UniProt Entry Name
SPTCA_DROME
UniProt Comments for alpha-SNCO
Function: Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Essential for larval survival and development. Stabilizes cell to cell interactions that are critical for the maintenance of cell shape and subcellular organization within embryonic tissues. Lva and spectrin may form a Golgi-based scaffold that mediates interaction of Golgi bodies with microtubules and facilitates Golgi-derived membrane secretion required for the formation of furrows during cellularization. Ref.5 Ref.7 Ref.8
Subunit structure: Native spectrin molecule is a tetramer composed of two antiparallel heterodimers joined head to head so that each end of the native molecule includes the C-terminus of the alpha subunit and the N-terminus of the beta subunit. Interacts with calmodulin in a calcium-dependent manner, interacts with F-actin and also interacts with Lva. Interacts with Ten-m. Ref.8 Ref.13
Subcellular location: Cytoplasm › cytoskeleton. Golgi apparatus. Note: Near the inner surface of the plasma membrane of nearly all cells. Lva-alpha-spectrin complexes are found at the Golgi. Ref.8
Tissue specificity: A substantial pool of maternal protein in the egg undergoes dynamic changes in distribution early in embryogenesis. In gastrulated embryo, the highest level of protein is found in the respiratory tract cells and the lowest in parts of the forming gut. Ref.9
Developmental stage: Expressed both maternally and zygotically.
Miscellaneous: Its transcript shares the first untranslated exon with the dlt transcript, suggesting a common regulation.
Sequence similarities: Belongs to the spectrin family.Contains 2 EF-hand domains.Contains 1 SH3 domain.Contains 22 spectrin repeats.
Sequence caution: The sequence AAL39886.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence ABA81823.1 differs from that shown. Reason: Frameshift at position 1549.
Research Articles on alpha-SNCO
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Pathways associated with alpha-SNCO elisa kit
Diseases associated with alpha-SNCO elisa kit
Organs/Tissues associated with alpha-SNCO elisa kit
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