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COL1A1 elisa kit :: Porcine collagen, type I, alpha 1 (COL1A1) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7251245
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

collagen, type I, alpha 1 (COL1A1), ELISA Kit

★Popular Item★
 Also Known As   

Porcine collagen, type I, alpha 1 (COL1A1) ELISA Kit

 Product Gene Name   

COL1A1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    607907
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 Species Reactivity    Porcine
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 Specificity    This assay has high sensitivity and excellent specificity for detection of COL1?1. No significant cross-reactivity or interference between COL1?1 and analogues was observed. NOTE: Limited by current skills and knowledge, it is impossible for us to complete the cross-reactivity detection between COL1?1 and all the analogues, therefore, cross reaction may still exist in some cases.
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 Samples    Serum, plasma, cell culture supernatants, body fluid and tissue homogenate
 Sensitivity    1.0 ng/mL
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of COL1A1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for COL1A1 purchase    MBS7251245 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the collagen, type I, alpha 1 (COL1A1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing COL1A1, with an estimated sensitivity of 1.0 ng/mL. The ELISA analytical biochemical technique of the MBS7251245 kit is based on COL1A1 antibody-COL1A1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect COL1A1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, COL1A1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, cell culture supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for COL1A1 elisa kit

   Intended Uses: This COL1?1 ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Porcine COL1?1. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
 Product Categories/Family for COL1A1 elisa kit    Signal Transduction
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 Typical Testing Data/Standard Curve (for reference only) of COL1A1 elisa kit    COL1A1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS7251245. Click to request current manual
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NCBI/Uniprot data below describe general gene information for COL1A1. It may not necessarily be applicable to this product.
 NCBI GI #    22328092
 NCBI GeneID    1277
 NCBI Accession #    AAH36531.1 [Other Products]
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 UniProt Secondary Accession #    O76045; P78441; Q13896; Q13902; Q13903; Q14037; Q14992; Q15176; Q15201; Q16050; Q59F64 [Other Products]
 UniProt Related Accession #    P02452 [Other Products]
 Molecular Weight    138,941 Da
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 NCBI Official Full Name    Collagen, type I, alpha 1
 NCBI Official Synonym Full Names    collagen, type I, alpha 1
 NCBI Official Symbol    COL1A1 [Similar Products]
 NCBI Official Synonym Symbols   
OI4
[Similar Products]
 NCBI Protein Information    collagen alpha-1(I) chain; collagen alpha-1(I) chain; alpha-1 type I collagen; pro-alpha-1 collagen type 1; collagen alpha 1 chain type I; collagen alpha-1(I) chain preproprotein; collagen of skin, tendon and bone, alpha-1 chain
 UniProt Protein Name    Collagen alpha-1(I) chain
 UniProt Synonym Protein Names   
Alpha-1 type I collagen
 Protein Family    Collagen
 UniProt Gene Name    COL1A1 [Similar Products]
 UniProt Entry Name    CO1A1_HUMAN
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 NCBI Summary for COL1A1    This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
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 UniProt Comments for COL1A1    COL1A1: Type I collagen is a member of group I collagen (fibrillar forming collagen). Defects in COL1A1 are the cause of Caffey disease (CAFFD); also known as infantile cortical hyperostosis. Caffey disease is characterized by an infantile episode of massive subperiosteal new bone formation that typically involves the diaphyses of the long bones, mandible, and clavicles. The involved bones may also appear inflamed, with painful swelling and systemic fever often accompanying the illness. The bone changes usually begin before 5 months of age and resolve before 2 years of age. Defects in COL1A1 are a cause of Ehlers-Danlos syndrome type 1 (EDS1); also known as Ehlers-Danlos syndrome gravis. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome. Defects in COL1A1 are the cause of Ehlers-Danlos syndrome type 7A (EDS7A); also known as autosomal dominant Ehlers-Danlos syndrome type VII. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7A is marked by bilateral congenital hip dislocation, hyperlaxity of the joints, and recurrent partial dislocations. Defects in COL1A1 are a cause of osteogenesis imperfecta type 1 (OI1). A dominantly inherited connective tissue disorder characterized by bone fragility and blue sclerae. Osteogenesis imperfecta type 1 is non-deforming with normal height or mild short stature, and no dentinogenesis imperfecta. Defects in COL1A1 are a cause of osteogenesis imperfecta type 2 (OI2); also known as osteogenesis imperfecta congenita. A connective tissue disorder characterized by bone fragility, with many perinatal fractures, severe bowing of long bones, undermineralization, and death in the perinatal period due to respiratory insufficiency. Defects in COL1A1 are a cause of osteogenesis imperfecta type 3 (OI3). A connective tissue disorder characterized by progressively deforming bones, very short stature, a triangular face, severe scoliosis, grayish sclera, and dentinogenesis imperfecta. Defects in COL1A1 are a cause of osteogenesis imperfecta type 4 (OI4); also known as osteogenesis imperfecta with normal sclerae. A connective tissue disorder characterized by moderately short stature, mild to moderate scoliosis, grayish or white sclera and dentinogenesis imperfecta. Genetic variations in COL1A1 are a cause of susceptibility to osteoporosis (OSTEOP); also known as involutional or senile osteoporosis or postmenopausal osteoporosis. Osteoporosis is characterized by reduced bone mass, disruption of bone microarchitecture without alteration in the composition of bone. Osteoporotic bones are more at risk of fracture. A chromosomal aberration involving COL1A1 is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGF. Belongs to the fibrillar collagen family.

Protein type: Extracellular matrix; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q21.33

Cellular Component: Golgi apparatus; extracellular matrix; extracellular space; endoplasmic reticulum lumen; collagen type I; extracellular region; secretory granule

Molecular Function: identical protein binding; protein binding; metal ion binding; extracellular matrix structural constituent; platelet-derived growth factor binding

Biological Process: response to peptide hormone stimulus; intramembranous ossification; extracellular matrix organization and biogenesis; collagen fibril organization; response to cAMP; positive regulation of transcription, DNA-dependent; embryonic skeletal development; response to estradiol stimulus; response to corticosteroid stimulus; extracellular matrix disassembly; protein transport; sensory perception of sound; visual perception; collagen biosynthetic process; skeletal development; endochondral ossification; response to drug; blood vessel development; receptor-mediated endocytosis; platelet activation; skin morphogenesis; osteoblast differentiation; collagen catabolic process; response to hyperoxia; response to hydrogen peroxide; blood coagulation; leukocyte migration; positive regulation of cell migration

Disease: Osteogenesis Imperfecta, Type I; Ehlers-danlos Syndrome, Type Vii, Autosomal Dominant; Osteogenesis Imperfecta, Type Ii; Ehlers-danlos Syndrome, Type I; Osteogenesis Imperfecta, Type Iii; Caffey Disease; Osteoporosis; Osteogenesis Imperfecta, Type Iv
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 Research Articles on COL1A1    1. A2AR activation downstream signaling for Col1 and Col3 expression proceeds via two distinct pathways with varying sensitivity to cAMP activation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with COL1A1 elisa kitDiseases associated with COL1A1 elisa kit
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Disease Name  Pubmed Publications
 Osteogenesis Imperfecta Antibodies  >279 publications with COL1A1 and Osteogenesis Imperfecta
 Fibrosis Antibodies  >182 publications with COL1A1 and Fibrosis
 Osteoporosis Antibodies  >121 publications with COL1A1 and Osteoporosis
 Disease Models, Animal Antibodies  >89 publications with COL1A1 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >77 publications with COL1A1 and Cardiovascular Diseases
 Inflammation Antibodies  >66 publications with COL1A1 and Inflammation
 Liver Diseases Antibodies  >44 publications with COL1A1 and Liver Diseases
 Heart Diseases Antibodies  >34 publications with COL1A1 and Heart Diseases
 Necrosis Antibodies  >32 publications with COL1A1 and Necrosis
 Liver Cirrhosis Antibodies  >26 publications with COL1A1 and Liver Cirrhosis
Organs/Tissues associated with COL1A1 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >580 publications with COL1A1 and Bone
 Connective Tissue Antibodies  >250 publications with COL1A1 and Connective Tissue
 Skin Antibodies  >231 publications with COL1A1 and Skin
 Blood Antibodies  >132 publications with COL1A1 and Blood
 Muscle Antibodies  >132 publications with COL1A1 and Muscle
 Bone Marrow Antibodies  >94 publications with COL1A1 and Bone Marrow
 Liver Antibodies  >75 publications with COL1A1 and Liver
 Vascular Antibodies  >75 publications with COL1A1 and Vascular
 Lung Antibodies  >65 publications with COL1A1 and Lung
 Heart Antibodies  >48 publications with COL1A1 and Heart
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