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HSPA5 elisa kit :: Rabbit 78 kDa glucose-regulated protein (HSPA5) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7249944 HSPA5 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

78 kDa glucose-regulated protein (HSPA5), ELISA Kit

 Also Known As   

Rabbit 78 kDa glucose-regulated protein (HSPA5) ELISA Kit

 Product Gene Name   

HSPA5 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 OMIM    138120
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 Species Reactivity    Rabbit
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of HSPA5 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for HSPA5 purchase    MBS7249944 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 78 kDa glucose-regulated protein (HSPA5) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing HSPA5. The ELISA analytical biochemical technique of the MBS7249944 kit is based on HSPA5 antibody-HSPA5 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HSPA5 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HSPA5. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for HSPA5. It may not necessarily be applicable to this product.
 NCBI GI #    16507237
 NCBI GeneID    3309
 NCBI Accession #    NP_005338.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005347.4 [Other Products]
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 UniProt Secondary Accession #    Q2EF78; Q9NPF1; Q9UK02; B0QZ61 [Other Products]
 UniProt Related Accession #    P11021 [Other Products]
 Molecular Weight    72,333 Da
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 NCBI Official Full Name    78 kDa glucose-regulated protein
 NCBI Official Synonym Full Names    heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
 NCBI Official Symbol    HSPA5 [Similar Products]
 NCBI Official Synonym Symbols   
BIP; MIF2; GRP78; HEL-S-89n
[Similar Products]
 NCBI Protein Information    78 kDa glucose-regulated protein; immunoglobulin heavy chain-binding protein; epididymis secretory sperm binding protein Li 89n; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
 UniProt Protein Name    78 kDa glucose-regulated protein
 UniProt Synonym Protein Names   
Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP
 UniProt Gene Name    HSPA5 [Similar Products]
 UniProt Synonym Gene Names    GRP78; GRP-78; BiP [Similar Products]
 UniProt Entry Name    GRP78_HUMAN
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 NCBI Summary for HSPA5    The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]
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 UniProt Comments for HSPA5    GRP78: a member of the HSP family of molecular chaperones required for endoplasmic reticulum integrity and stress-induced autophagy. Plays a central role in regulating the unfolded protein response (UPR), and is an obligatory component of autophagy in mammalian cells. May play an important role in cellular adaptation and oncogenic survival. One of the client proteins of GRP78 is protein double-stranded RNA-activated protein-like endoplasmic reticulum kinase (PERK). Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

Protein type: Heat shock protein; Chaperone

Chromosomal Location of Human Ortholog: 9q33.3

Cellular Component: signalosome; endoplasmic reticulum membrane; focal adhesion; cell surface; smooth endoplasmic reticulum; mitochondrion; endoplasmic reticulum lumen; endoplasmic reticulum; ER-Golgi intermediate compartment; membrane; plasma membrane; melanosome; integral to endoplasmic reticulum membrane; midbody; nucleus

Molecular Function: protein domain specific binding; protein binding; enzyme binding; chaperone binding; ubiquitin protein ligase binding; unfolded protein binding; ATPase activity; ribosome binding; calcium ion binding; misfolded protein binding; glycoprotein binding; ATP binding

Biological Process: platelet activation; ER-associated protein catabolic process; cerebellum structural organization; unfolded protein response; cerebellar Purkinje cell layer development; cellular response to glucose starvation; substantia nigra development; cellular protein metabolic process; platelet degranulation; unfolded protein response, activation of signaling protein activity; positive regulation of protein ubiquitination; negative regulation of transforming growth factor beta receptor signaling pathway; blood coagulation; ER overload response; positive regulation of cell migration; negative regulation of apoptosis
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 Research Articles on HSPA5    1. The secreted recombinant human BiP possesses native amino acid sequence and structural integrity, is biologically active and without yeast-derived modifications.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HSPA5 elisa kitPathways associated with HSPA5 elisa kit
 Reference Product  PubMed Publications
 ATF6 elisa kit  >29 publications with HSPA5 and ATF6
 ATF4 elisa kit  >26 publications with HSPA5 and ATF4
 ERN1 elisa kit  >8 publications with HSPA5 and ERN1
 HYOU1 elisa kit  >7 publications with HSPA5 and HYOU1
 SIL1 elisa kit  >5 publications with HSPA5 and SIL1
 EIF2AK3 elisa kit  >2 publications with HSPA5 and EIF2AK3
 Products by Pathway  Pathway Diagram
 ATF6-alpha Activates Chaperone Genes Pathway antibodies  ATF6-alpha Activates Chaperone Genes Pathway Diagram
 ATF6-alpha Activates Chaperones Pathway antibodies  ATF6-alpha Activates Chaperones Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 IRE1alpha Activates Chaperones Pathway antibodies  IRE1alpha Activates Chaperones Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with HSPA5 elisa kitOrgans/Tissues associated with HSPA5 elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >59 publications with HSPA5 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >56 publications with HSPA5 and Disease Models, Animal
 Nervous System Diseases Antibodies  >55 publications with HSPA5 and Nervous System Diseases
 Inflammation Antibodies  >33 publications with HSPA5 and Inflammation
 Liver Diseases Antibodies  >21 publications with HSPA5 and Liver Diseases
 Heart Diseases Antibodies  >20 publications with HSPA5 and Heart Diseases
 Necrosis Antibodies  >19 publications with HSPA5 and Necrosis
 Kidney Diseases Antibodies  >13 publications with HSPA5 and Kidney Diseases
 Fibrosis Antibodies  >10 publications with HSPA5 and Fibrosis
 Fatty Liver Antibodies  >10 publications with HSPA5 and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >75 publications with HSPA5 and Brain
 Muscle Antibodies  >48 publications with HSPA5 and Muscle
 Blood Antibodies  >45 publications with HSPA5 and Blood
 Heart Antibodies  >38 publications with HSPA5 and Heart
 Liver Antibodies  >38 publications with HSPA5 and Liver
 Kidney Antibodies  >30 publications with HSPA5 and Kidney
 Nerve Antibodies  >20 publications with HSPA5 and Nerve
 Vascular Antibodies  >20 publications with HSPA5 and Vascular
 Pancreas Antibodies  >16 publications with HSPA5 and Pancreas
 Lung Antibodies  >14 publications with HSPA5 and Lung
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