Q9UNA0.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
101,718 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 5
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif, 5
NCBI Official Synonym Symbols
ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11 [Similar Products]
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 5; aggrecanase-2; a disintegrin and metalloproteinase with thrombospondin motifs 11; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 5
UniProt Synonym Protein Names
A disintegrin and metalloproteinase with thrombospondin motifs 11; ADAM-TS 11; ADAMTS-11; ADMP-2; Aggrecanase-2
UniProt Synonym Gene Names
ADAMTS11; ADMP2; ADAM-TS 5; ADAM-TS5; ADAMTS-5; ADAM-TS 11; ADAMTS-11 [Similar Products]
UniProt Entry Name
ATS5_HUMAN
NCBI Summary for ADAM11
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq, Jul 2008]
UniProt Comments for ADAM11
ADAMTS5: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.
Protein type: Motility/polarity/chemotaxis; Secreted; EC 3.4.24.-; Extracellular matrix; Secreted, signal peptide; Protease
Chromosomal Location of Human Ortholog: 21q21.3
Cellular Component: proteinaceous extracellular matrix; endoplasmic reticulum lumen; extracellular region
Molecular Function: integrin binding; protein binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity
Biological Process: extracellular matrix disassembly; protein amino acid O-linked glycosylation; extracellular matrix organization and biogenesis; cellular protein metabolic process; defense response to bacterium; post-translational protein modification; proteolysis
Research Articles on ADAM11
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Products associated with ADAM11 elisa kit
Pathways associated with ADAM11 elisa kit
Diseases associated with ADAM11 elisa kit
Organs/Tissues associated with ADAM11 elisa kit
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