NP_955387.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
119,768 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 18 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif, 18
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 18; disintegrin and metalloprotease-like protein; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 21
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 18
UniProt Synonym Gene Names
UniProt Entry Name
ATS18_HUMAN
NCBI Summary for ADAMTS18
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for ADAMTS18
ADAMTS18: Defects in ADAMTS18 are the cause of Knobloch syndrome type 2 (KNO2). A developmental disorder primarily characterized by typical eye abnormalities, including high myopia, cataracts, dislocated lens, vitreoretinal degeneration, and retinal detachment, with occipital skull defects, which can range from occipital encephalocele to occult cutis aplasia. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Motility/polarity/chemotaxis; EC 3.4.24.-; Protease; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 16q23
Cellular Component: proteinaceous extracellular matrix
Molecular Function: zinc ion binding; metalloendopeptidase activity
Biological Process: eye development; proteolysis
Disease: Microcornea, Myopic Chorioretinal Atrophy, And Telecanthus
Research Articles on ADAMTS18
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Products associated with ADAMTS18 elisa kit
Pathways associated with ADAMTS18 elisa kit
Diseases associated with ADAMTS18 elisa kit
Organs/Tissues associated with ADAMTS18 elisa kit
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