NP_112503.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,518 Da
NCBI Official Full Name
aromatase
NCBI Official Synonym Full Names
cytochrome P450, family 19, subfamily A, polypeptide 1
NCBI Official Synonym Symbols
ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM [Similar Products]
NCBI Protein Information
aromatase; cytochrome P-450AROM; cytochrome P450 19A1; cytochrome P450, subfamily XIX (aromatization of androgens); estrogen synthase; estrogen synthetase; flavoprotein-linked monooxygenase; microsomal monooxygenase
UniProt Protein Name
Aromatase
UniProt Synonym Protein Names
CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase
UniProt Synonym Gene Names
UniProt Entry Name
CP19A_HUMAN
NCBI Summary for ARO
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
UniProt Comments for ARO
CYP19A1: Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Belongs to the cytochrome P450 family.
Protein type: EC 1.14.14.14; Lipid Metabolism - androgen and estrogen; Oxidoreductase
Chromosomal Location of Human Ortholog: 15q21.1
Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum
Molecular Function: electron carrier activity; iron ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxygen binding
Biological Process: steroid metabolic process; xenobiotic metabolic process; androgen metabolic process; estrogen biosynthetic process; steroid biosynthetic process; sterol metabolic process
Disease: Aromatase Deficiency; Aromatase Excess Syndrome
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Pathways associated with ARO elisa kit
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Cytochrome P450 - Arranged By Substrate Type Pathway Diagram |
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Defective CYP17A1 Causes Adrenal Hyperplasia 5 (AH5) Pathway Diagram |
Defective CYP19A1 Causes Aromatase Excess Syndrome (AEXS) Pathway antibodies |
Defective CYP19A1 Causes Aromatase Excess Syndrome (AEXS) Pathway Diagram |
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Diseases associated with ARO elisa kit
Organs/Tissues associated with ARO elisa kit
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