NP_000211.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,611 Da
NCBI Official Full Name
ATP-sensitive inward rectifier potassium channel 1 isoform a
NCBI Official Synonym Full Names
potassium inwardly-rectifying channel, subfamily J, member 1
NCBI Protein Information
ATP-sensitive inward rectifier potassium channel 1; inwardly rectifying K+ channel; inward rectifier K(+) channel Kir1.1; ATP-regulated potassium channel ROM-K; potassium channel, inwardly rectifying subfamily J member 1
UniProt Protein Name
ATP-sensitive inward rectifier potassium channel 1
UniProt Synonym Protein Names
ATP-regulated potassium channel ROM-K; Inward rectifier K(+) channel Kir1.1; Potassium channel, inwardly rectifying subfamily J member 1
UniProt Synonym Gene Names
UniProt Entry Name
KCNJ1_HUMAN
NCBI Summary for KCNJ1
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNJ1
ROMK: an inward rectifier-type potassium channel protein. Probably plays a major role in potassium homeostasis in the kidney. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. The channel is activated by internal ATP and can be blocked by external barium. High levels of expression in the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver. Three alternatively spliced isoforms have been described.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium
Chromosomal Location of Human Ortholog: 11q24
Cellular Component: voltage-gated potassium channel complex; plasma membrane
Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; ATP-activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; ATP binding
Biological Process: synaptic transmission; potassium ion import; tissue homeostasis; excretion; kidney development; potassium ion transport; post-embryonic development
Disease: Bartter Syndrome, Antenatal, Type 2
Research Articles on KCNJ1
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Products associated with KCNJ1 elisa kit
Pathways associated with KCNJ1 elisa kit
Diseases associated with KCNJ1 elisa kit
Organs/Tissues associated with KCNJ1 elisa kit
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