NP_001278893.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
207,788 Da
NCBI Official Full Name
afadin isoform 4
NCBI Official Synonym Full Names
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
NCBI Official Synonym Symbols
NCBI Protein Information
afadin; protein AF-6; ALL1-fused gene from chromosome 6 protein
UniProt Protein Name
Afadin
UniProt Synonym Protein Names
ALL1-fused gene from chromosome 6 protein; Protein AF-6
UniProt Synonym Gene Names
UniProt Entry Name
AFAD_HUMAN
NCBI Summary for MLLT4
This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011]
UniProt Comments for MLLT4
Afadin: plays a role in adhesion by participating, along with E-cadherin and catenin, in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Essential for the association of nectin and E-cadherin. Contains 1 forkhead-associated (FHA) domain, a phosphopeptide recognition domain; 1 dilute (DIL) domain, a myosin-like domain which may play a functional role in cellular processes or vectorial vesicle transport; 1 PDZ domain, which frequently binds the carboxyl-terminal sequences of proteins or phosphatidylinositol 4,5-bisphosphate in the plasma membrane; and 2 RA domains, which are associated with RasGTP effector activity. Five alternatively spliced isoforms have been described. Isoform 2 does not interact with F-actin.
Protein type: Motility/polarity/chemotaxis; Cell adhesion; Oncoprotein
Chromosomal Location of Human Ortholog: 6q27
Cellular Component: nucleoplasm; cell-cell adherens junction; apical part of cell; cytoplasm; plasma membrane; intercellular junction; cell junction; cytosol
Molecular Function: protein C-terminus binding; protein binding; Ras GTPase binding; cell adhesion molecule binding
Biological Process: intercellular junction assembly and maintenance; cell-cell signaling; cell adhesion; signal transduction
Research Articles on MLLT4
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Products associated with MLLT4 elisa kit
Pathways associated with MLLT4 elisa kit
Diseases associated with MLLT4 elisa kit
Organs/Tissues associated with MLLT4 elisa kit
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